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    张媛媛简介

    发布时间:2016/6/3 编辑:白霜 作者:system 点击:1452

      张媛媛,博士,现任四川大学药理教研室副教授,硕士生导师。

      教育及工作经历:

      1997年9月—2001年7月

      中国药科大学,药物制剂专业,学士

      2001年9月—2006年7月

      中国科学院上海生命科学研究院,生物化学与分子生物学专业,硕博连读

      2006年7月—2007年7月

      香港大学李嘉诚医学院内科系

      2007年7月—2010年7月

      复旦大学生命科学学院微生物学与微生物工程系

      2010年7月至今

      四川大学华西基础医学与法医学院药理教研室

      基金:

      1、主持并完成复旦大学青年科学基金一项

      2、主持2009年度国家自然科学基金青年基金一项(项目编号:30900561)

      3、主持2009年度博士点新教师基金一项

      研究方向:

      1、中药单体抗肿瘤,尤其是抗肝癌转移的信号转导通路研究

      2、柯萨奇B3病毒引起的炎症及纤维化分子信号通路,以及中药单体抗炎抗纤维化分子机制

      学术兼职:

      本人为Life Sciences等期刊担任审稿人,是RNA & Disease, American Journal of Medical Sciences and Medicine, ARC Journal of Cancer Science编委会成员, 是Journal of Clinical and Translational Hepatology科学编辑。现任四川药理学会理事,中国药理学会网络药理学专委会委员,中国医学促进会徇证医学分会委员。

      学术论文:

      1. Liu ZR, Song Y, Wan LH, Zhang YY*, Zhou LM*. Over-expression of miR-451a can enhance the sensitivity of breast cancer cells to tamoxifen by regulating 14-3-3ζ,estrogen receptor α, and autophagy. Life Sciences 2016; 149: 104-13.

      2. Xiong Y, Zhang YY, Wu YY, Wang XD, Wan LH, Li L, Zhou LM. Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages. Life Sciences 2014; 106(1-2):19-24.

      3. Xiong Y, Ma XY, Zhang Z, Shao ZJ, Zhang YY, Zhou LM. Apoptosis induced by β,β-dimethylacrylshikonin is associated with Bcl-2 and NF-κB in human breast carcinoma MCF-7 cells. Oncology Letters 2013; 6(6): 1789-93.

      4. Zhang YY, Li JN, Xia HHX, Zhang SL, Zhong J, Wu YY, Miao SK, Zhou LM. Protective effects of losartan in mice with chronic viral myocarditis induced by coxsackievirus B3. Life Sciences 2013; 92(24-26):1186-94.

      5. Xiong Y, Ma XY, Zhang Z, Shao ZJ, Zhang YY, Zhou LM. Apoptosis induced by β,β-Dimethylacrylshikonin is associated with Bcl-2 and NF-kB in human breast carcinoma MCF-7 cells. Oncol Lett 2013; 6(6): 1789-1793.

      6. Jin SJ, Ma XY, Zhang YY, Wan LH, Zhao Y, Zhou LM. Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo. Phytotherapy Research 2013 doi: 10.1002/ptr.5024.

      7. Zhang YY, Zhou LM. Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells. European Journal of Pharmacology 2013;698(1-3):137-44.

      8. Shao ZJ, Zhang YY (并列第一), Fan YY, Jin SJ, Yan J, Zheng XW, Chen J, Xiong Y, Zhou LM. β,β-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo. Biochemical Pharmacology 2012; 84(4): 507-512.

      9. Zhang YY, Zhou LM. Sirt3 inhibits hepatocellular cell growth through reducing Mdm2-mediated p53 degradation. Biochemical and Biophysical Research Communications  2012; 423 (1): 26-31.

      10.张媛媛,周黎明。药理学教学在以疾病为中心的医学培养模式中的探索。《中国药理通讯》,2012;4:19-22.

      11. Hu ZP, Yin J, Zhang YY, Jia SY, Chen ZJ, Zhong J. Characterization of the immune responses elicited by baculovirus-based vector vaccines against influenza virus hemagglutinin. Acta Pharmcol Sin 2012; 33(6): 783-90.

      12. Zhu HY, Huang H, Zhang YY, Chen HS, Wang B, Ye G, et al. Antiviral effects of Yin-Zhi-Ku extract against human and duck hepatitis B virus replication. Asian Chemistry Letters 2011; 5(4): 1-10.

      13. Xia HH, Yang Y, Chu KM, Gu Q, Zhang YY, He H, Wong WM, Leung SY, Yuen ST, Yuen MF, Chan AO, Wong BC.Serum macrophage migration-inhibitory factor as a diagnostic and prognostic biomarker for gastric cancer. Cancer. 2009 Dec 1;115(23):5441-9.

      14. ZhangYY, Xia HH, Zhuang ZH, Zhong J. “True” re-infection of Helicobacter pylori after successful eradication: Worldwide annual rates, risk factors and clinical implications. Alimentary Pharmacology & Therapeutics 2009;29(2):145-60.

      15. Zhu HY, Zhang YY, Ye G, Li ZX, Zhou P, Huang CG. In vivo and in vitro antiviral activities of Calycosin-7-O-β-D-glucopyranoside against coxsackievirus B3. Biological & Pharmaceutical Bulletin 2009; 32(1): 68-73.

      16.张媛媛,钟江。手足口病与肠道病毒71型。《微生物与感染》,2008;3(2):97-99。

      17. Zhang YY, Xia HH. Novel therapeutic approaches for hepatocellulcar carcinoma: fact and fiction. World J Gastroenterology 2008 ;14(11):1641-2.

      18. Tang YH, Zhang YY, Zhu HY, Huang CG. A high-performance liquid chromatographic method for saikosaponin a quantification in rat plasma. Biomedical Chromatography 2007; 21: 458-462.

      19. Zhang YY, Zhu HY, Ye G, Huang CG, Yang YZ, Chen RZ, Yu Y, Cui XL. Antiviral effects of Sophoridine against Coxsackievirus B3 and its pharmacokinetics in rats. Life Sciences 2006; 78: 1998-2005.

      20. Zhang YY, Zhu HY, Huang CG, Cui XL, Gao YJ, Huang Y, Gong WF, Zhao Y, Guo SS. Astragaloside IV exerts its antivirus effects against Coxsackievirus B3 by upregulating IFN-γ. Journal of Cardiovascular Pharmacology 2006; 47: 190-197.

      21. Tang YH, Zhu HY, Zhang YY, Huang CG. Determination of human plasma protein binding of baicalin by ultrafiltration and high-performance liquid chromatography. Biomedical Chromatography 2006; 20(10): 1116-1119.

       

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