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    万莉红简介

    发布时间:2016/6/3 编辑:白霜 作者:system 点击:1522

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      现任四川大学基础与法医学院药理学教研室副教授。

      研究方向

      1 主要从事神经药理学及时间药理学的相关研究,尤其是与学习记忆相关的近日节律基因的信号转导、基因调控。

      2 炎症药理学:主攻气道重塑相关性疾病(哮喘、慢阻肺)治疗药物的分子机制研究。

      科研项目

      作为负责人共主持国家自然科学基金面上项目1项“RACK1调控支气管上皮细胞损伤-修复过程在哮喘气道重塑中的作用机制及大环内酯类药物的干预作用”(No. 81470224);国家自然科学基金青年基金1项“新的节律分子RACK1参与调控吗啡成瘾记忆的机制研究”(No. 81100989);国家自然科学基金国家基础科学人才培养基金能力提高项目1项“RACK1/BDNF信号通路对SAMP/8快速老化小鼠脑内淀粉样斑块沉积及学习记忆能力障碍的调控作用”(No. J1103604);四川省中医药管理局青年中医药项目1项“复方丹参片对老年性痴呆小鼠学习记忆功能影响及神经保护”;四川大学青年教师科研启动基金项目1项以及横向协作项目多项。

      学术论文

      共发表科研学术论文60余篇,其中SCI论文20篇;第一作者(通讯作者)SCI论文14篇。

      1. Wan L, Su L, Xie Y, Liu Y, Wang Y, Wang Z. Protein receptor for activated C kinase 1 is involved in morphine reward in mice. Neuroscience, 2009, 161(3): 734-42.

      2. Wan Lihong, Wang Zhengrong, Zhou Liming. Protecting Effects of Emodin on Multiorgan Failure of Rats With Severe Acute Pancreatitis. Pancreas, 2009, 38(7): 835-836.

      3. Wan LH, Chen J, Li L, Xiong WB, Zhou LM. Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats. Pharmaceutical Biology, 2011, 49(11): 1204-1209.

      4. Wan L, Xie Y, Su L, Liu Y, Wang Y, Wang Z. RACK1 affects morphine reward via BDNF. Brain Res, 2011, 1416: 26-34.

      5. Zhou Y, Tan X, Kuang W, Liu L, Wan L*. Erythromycin ameliorates cigarette-smoke–induced emphysema and inflammation in rats. Transl Res, 2012, 159(6): 464-472.

      6. Li LK, Kuang WJ, Huang YF, Xie HH, Chen G, Zhou QC, Wang BR, Wan LH*. Anti-tumor effects of Astragalus on hepatocellular carcinoma in vivo. Indian J Pharmacol, 2012, 44(1): 78-81.

      7. Wu YYa, Wan LHa, Zheng XW, Shao ZJ, Chen J, Chen XJ, Liu LT, Kuang WJ, Tan XS, Zhou LM. Inhibitory Effects of β,β-Dimethylacrylshikonin on Hepatocellular Carcinoma In Vitro and In Vivo. Phytother Res, 2012, 26(5):764-71.

      8. L. Wan, L. Liu, Z. Zhang, Y. Zhou, Y. Xiong, D. Li and L. Zhou. Low-dose azithromycin attenuates OVA-induced airway remodeling and inflammation via down-regulating TGF-β1 expression in rat. Euro J Inflam, 2013, 1(1): 133-145.

      9. Liu LTa, Wan LHa, Song XH, Xiong Y, Jin SJ, Zhou LM. Relevance of class 1 integrons and extended?spectrum β?lactamases in drug?resistant Escherichia coli. Mol Med Rep, 2013 Oct, 8(4): 1251-5.   

      10. Teng Y, Zhang MQ, Wang W, Liu LT, Zhou LM, Miao SK, Wan LH*. Compound danshen tablet ameliorated abeta25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins. BMC Complement Altern Med, 2014 Jan, 14(1): 23.   

      11. Li-Tao LIU, Jie-Jun ZHU, Li-Hong WAN*a, Li-Ming ZHOU*a. Alcohol-induced reward memory is positively associated with persistent high levels of RACK1, LC3-II/I and synaptophysin in hippocampus of C57BL/6J mice. J NEUROL SCI-TURK, 2015, 32(4): 718-727.  

      12. Zhou Y, Liao S, Zhang Z, Wang B, Wan L*. Astragalus injection attenuates bleomycin-induced pulmonary fibrosis via down-regulating Jagged1/Notch1 in lungs. J Pharm Pharmacol, 2016 Mar; 68(3): 389-96.  

      13. Liu L, Zhu J, Zhou L, Wan L*. RACK1 promotes maintenance of morphine-associated memory via activation of an ERK-CREB dependent pathway in hippocampus. Sci Rep, 2016 Feb, 6: 20183. 

      14. Zhu J, Chen X, Song Y, Zhang Y, Zhou L, Wan L*. Deficit of RACK1 contribute to the spatial memory impairment via up regulating BECLIN1 to induce autophagy. Life Sci, 2016 Feb 27. pii: S0024-3205(16)30064-9.

       

      学术兼职

      现任四川省生理科学会理事,四川省健康管理师协会安全用药专委会常务理事,《四川生理科学杂志》编委,SCI期刊 HUM EXP TOXICOL 特邀审稿人。

       

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