Associate Professor
Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University
Address: Room 24, 2/F, The Fifth Teaching Building, 17 Renmin South Road 3rd Section, West China College of Basic and Forensic Medicine, Sichuan University, Chengdu, 610041, P. R. China
Work phone: +86-28-8550 1278
Mobile phone: +86-187 2849 5257
Email: sarahyyzhang@hotmail.com
Education and training
China Pharmaceutical University, Bachelor, Pharmaceutics, 2001
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,
Biochemistry and molecular biology, 2006
Dr. Zhang focus on the tumor microenvironment and molecular mechanisms of anti-tumor effects of compounds extracted from Traditional Chinese Medicines. She has got financial foundation from National National Science Foundation of China, and Ph.D. Programs Foundation of Ministry of Education of China. She has published dozens of academic articles in SCI journals. She also published a book as the editor-in-chief. She paid a lot of efforts to teaching and obtained several teaching awards.
Area of interest
Gastrointestinal Cancer, autophagy, non-coding RNA, R&D of antineoplastic drugs
Selected Publications：
1. Tian XT, Chen SJ, Zhang YY, Chen LY, Guo XZ, Xu Z, Liu H, Hu P, Chen ZY, Li ZX, Huang CG. Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of calycosin-7-O-β-D-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by HPLC-MS/MS.Journal of Pharmaceutical and Biomedical Analysis 2018; 148: 350-354.
2. Wu Y, Song Y, Xiong Y, Wang X, Xu K, Han B, Bai Y, Li L, Zhang Y (co-correspondence), Zhou L. MicroRNA-21 (Mir21) promotes cell growth and invasion by repressing tumor suppressor PTEN in colorectal cancer.Cell Physiol Biochem 2017; 43(3): 945-958.
3. Shi XW, Zhu HY*, Zhang YY, Zhou MM, Tang DL, Zhang HM. XuefuZhuyu decoction protected cardiomyocytes against hypoxia/ reoxygenation injury by inhibiting autophagy.BMC Complementary and Alternative Medicine 2017; 17(1): 35.
4. Xu K, Zhang YY (co-first author), Han B, Bai Y, Xiong Y, Song Y, Zhou LM. Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer-related gene.Tumor Biology 2017; 39(5): 1010428317705504.
5. Liao QJ, Zhang YY, Fan YC, Zheng MH, Bai Y, Eslick GD, He XX, Zhang SB, Xia HHX, He H. Perception of Chinese researchers towards academic misconduct: a comparison between 2015 and 2010.Science and Engineering Ethics 2017; doi: 10.1007/s11948-017-9913-3.
6. Liu ZR, Song Y, Wan LH, Zhang YY* (co-correspondence), Zhou LM*. Over-expression of miR-451a can enhance the sensitivity of breast cancer cells to tamoxifen by regulating 14-3-3ζ,estrogen receptor α, and autophagy.Life Sciences 2016; 149: 104-13.
7. Zhu J, Chen X, Song Y, Zhang Y, Zhou L, Wan L. Deficit of RACK1 contributes to the spatial memory impairment via upregulating BECLIN1 to induce autophagy.Life Sci. 2016; 151: 115-121
8. Xiong Y, Zhang YY, Wu YY, Wang XD, Wan LH, Li L, Zhou LM. Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages.Life Sciences 2014; 106(1-2):19-24.
9. Xiong Y, Ma XY, Zhang Z, Shao ZJ, Zhang YY, Zhou LM. Apoptosis induced byβ,β-dimethylacrylshikonin is associated with Bcl-2 and NF-κB in human breast carcinoma MCF-7 cells.Oncology Letters 2013; 6(6): 1789-93.
10. Zhang YY, Li JN, Xia HHX, Zhang SL, Zhong J, Wu YY, Miao SK, Zhou LM. Protective effects of losartan in mice with chronic viral myocarditis induced by coxsackievirus B3.Life Sciences 2013; 92(24-26):1186-94.
11. Jin SJ, Ma XY, Zhang YY, Wan LH, Zhao Y, Zhou LM. Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo.Phytotherapy Research 2014; 28(4): 560-7.
12. Zhang YY, Zhou LM. Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells.European Journal of Pharmacology 2013; 698(1-3): 137-44.
13. Shao ZJ, Zhang YY (co-first author), Fan YY, Jin SJ, Yan J, Zheng XW, Chen J, Xiong Y, Zhou LM. β,β-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo.Biochemical Pharmacology 2012; 84(4): 507-512.
14. Zhang YY, Zhou LM. Sirt3 inhibits hepatocellular cell growth through reducing Mdm2-mediated p53 degradation.Biochemical and Biophysical Research Communications 2012; 423 (1): 26-31.
15. Hu ZP, Yin J, Zhang YY, Jia SY, Chen ZJ, Zhong J. Characterization of the immune responses elicited by baculovirus-based vector vaccines against influenza virus hemagglutinin.Acta Pharmcol Sin 2012; 33(6): 783-90.
16. Zhu HY, Huang H, Zhang YY, Chen HS, Wang B, Ye G, et al. Antiviral effects of Yin-Zhi-Ku extract against human and duck hepatitis B virus replication.Asian Chemistry Letters 2011; 5(4): 1-10.
17. Xia HH, Yang Y, Chu KM, Gu Q, Zhang YY, He H, Wong WM, Leung SY, Yuen ST, Yuen MF, Chan AO, Wong BC. Serum macrophage migration-inhibitory factor as a diagnostic and prognostic biomarker for gastric cancer.Cancer. 2009 Dec 1;115(23):5441-9.
18. ZhangYY, Xia HH, Zhuang ZH, Zhong J. “True” re-infection of Helicobacter pylori after successful eradication: Worldwide annual rates, risk factors and clinical implications.Alimentary Pharmacology & Therapeutics 2009;29(2):145-60.
19. Zhu HY, Zhang YY, Ye G, Li ZX, Zhou P, Huang CG. In vivo and in vitro antiviral activities of Calycosin-7-O-β-D-glucopyranoside against coxsackievirus B3.Biological & Pharmaceutical Bulletin 2009; 32(1): 68-73.
20. Zhang YY, Xia HH. Novel therapeutic approaches for hepatocellulcar carcinoma: fact and fiction.World J Gastroenterology 2008 ;14(11):1641-2.
21. Tang YH, Zhang YY, Zhu HY, Huang CG. A high-performance liquid chromatographic method for saikosaponin a quantification in rat plasma.Biomedical Chromatography 2007; 21(5): 458-462.
22. Zhang YY, Zhu HY, Ye G, Huang CG, Yang YZ, Chen RZ, Yu Y, Cui XL. Antiviral effects of Sophoridine against Coxsackievirus B3 and its pharmacokinetics in rats.Life Sciences 2006; 78: 1998-2005.
23. Zhang YY, Zhu HY, Huang CG, Cui XL, Gao YJ, Huang Y, Gong WF, Zhao Y, Guo SS. Astragaloside IV exerts its antivirus effects against Coxsackievirus B3 by upregulating IFN-γ.Journal of Cardiovascular Pharmacology 2006; 47(2): 190-197.
24. Tang YH, Zhu HY, Zhang YY, Huang CG. Determination of human plasma protein binding of baicalin by ultrafiltration and high-performance liquid chromatography.Biomedical Chromatography 2006; 20(10): 1116-1119.