Professor
Department of Biochemistry &Molecular Biology,Sichuan University
Address: West China School of Basic Medical Sciences & Forensic Medicine, Yifu building, Room 213, Ren Ming South Street, Chengdu, Sichuan, P.R.China
Phone Number: (028)85501283
Email Address: qin_1@sin.com
Dr. Qin’s main research interests lie in the study of the mechanisms leading to the human hepatocellular carcinoma. Dr. Qin’research programsfocus on epigenetic biology mechanism in carcinogenesis, and biomarker of early warning and prognosis of human hepatocellular carcinoma. Dr. Qin has published more than 100 refereed papers and 5 book chapters. The publications has been appeared in FEBS J，FEBS letters , Cancer Letters, Genomics, and other journals
Education and trailing
Sichuan University Ph.D, Biochemistry & Molecular Biology, 2004
Beijing Medical University MS, Microbiology, 1987
Sichuan Medical college MD, Medicine, 1982
Research fellow supported by British Wellcome Trust project in Glasgow University, Molecular virology 1993-1994
Louven University, Belgium, Postdoctoc, Molecular virology, 1994-1995.10
Area of Interest
Methylation of tumor suppressor genes and biomarkers of early warning and prognosis of human hepatocellular carcinoma, regulation of imprinting genes, liver cancer stem cell
Selected publications
1.Liu Q, Chen K, Liu Z, Zhao R, et al., BORIS up-regulates OCT4 via histone methyloation to promote cancer stem cell-like properties in human liver cancer cells.Cancer Lett.2017, 403:165-174.
2.Yu X, Liu Q, He J, Huang Y, Jiang, et al., Vigilin interacts with CTCF and is involved in the maintenance of imprinting of IGF2 through a novel RNA-mediated mechanism.Int J Biolv Macromol. 2017 Nov 17.pii: S0141-8130(17)31378-8.
3.Wei L, Huang Y, Zhao R, Zhang J, et al., Detection of promoter methylation status of suppressor of cytokine signaling 3 (SOCS3) in tissue and plasma from Chinese patients with different hepatic diseases.Clin Exp Med. 2017 Sep 26. doi: 10.1007/s10238-017-0473-2.
4.He J, Huang Y, Liu Z, Zhao R, et al., Hypomethylation of BORIS is a promising prognostic biomarker in hepatocellular carcinoma.Gene. 2017, 629:29-34.
5.Liu ZJ, Huang Y, Wei L, et al., Combination of LINE-1 hypomethylation and RASSF1A promoter hypermethylation in serum DNA is a non-invasion prognostic biomarker for early recurrence of hepatocellular carcinoma after curative resection.Neoplasma.2017, 64:795-802.
6.Wei L, Xie X, Li J, et al..,.Disruption of human vigilin impairs chromosome condensation and segregation.Cell Biol Int.2015 ,39:1234-41.
7.Yang WL Wei L, Huang WQ, et al.,Vigilin is overexpressed in hepatocellular carcinoma and is required for HCC cell proliferation and tumor growth.Oncol Rep.2014, 31:2328- 34.
8.Liu Q, Yang B, Xie X, Wei L, et al.,Vigilin interacts with CCCTC-binding factor (CTCF) and is involved in CTCF-dependent regulation of the imprinted genes Igf2 and H19. 2014,FEBS J. 281, 2713–2725.
9.Shen WY, Liu QY, Wei L, et al..CTCF-mediated reduction of vigilin binding affects the binding of HP1a to the satellite 2.FEBS Lett.2014,588: 1549–15557.
10.Huang W,Li T,Yang W,et al.. Analysis of DNA Methylation in Plasma for Monitoring Hepatocarcinogenesis. See comment in PubMed Commons below.Genet Test Mol Biomarkers.2015,19(6):295-30296.
11.Chen K, Huang W, Huang B, et al..BORIS, brother of the regulator of imprinted sites, is aberrantly expressed in hepatocellular carcinoma.Genet Test Mol Biomarkers. 2013,17:160-5.
12.Jing Wu,Yang Qin, Li Bo，et al.. Hypomethylated and hypermethylated profiles ofH19DMR are associated with the aberrant imprinting ofIGF2andH19inhuman hepatocellular carcinoma.Genomics.2008, 91:443-450.
13. J hong Wang, Yang Qin, Bo Li, et al., Detection of Aberrant Promoter Methylation ofGSTP1inTumor and Serum from Human Primary Hepatocellular Carcinoma Patients of China.Clinical Biochemistry, 2006, 39: 344-348.
14.Qin Y, Liu JY, Li B,etal..Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis.World J Gastroenterol. 2004, 10:1276-1280