Name：Yang SHEN
Title：Professor,Master supervisor
Email：shenyang@scu.edu.cn; shenyang24@126.com
Background：
1998.09~2002.06,College of materials science and engineering，Zhengzhou University，Bachelor
2002.09~2005.06,College of Bioengineering，Chongqing University, Master
2007.05~2008.05, University of Missouri-Columbia, USA，Joint training of Doctoral Students
2005.09~2009.06,College of Bioengineering，Chongqing University, Phd
2015.1~2016.1, University of Pittsburgh，USA，Visiting scholar
2009.07~Now, Western China School of Basic Medical Science & Forensic Medical, Sichuan University, Professor
Research interest：
1. Mechanical pathogenic mechanism and interventional therapy in cardiovascular and Cerebral disease
2. Mechanical-chemical signaling transduction and drug targets of tumor angiogenesis
Project：
1. National Natural Science Fund of China, “The Investigation on the mechanobiological Mechanism of Mechanical Sensitive YAP Pathway Induced Fluid shear Stress Regulating Blood-brain Barrier”（31870939）, 2019.1－2022.12.
2. National Natural Science Fund of China,“ The Mechanobiological Mechanism of Cell Population and Their Synergistic Effects Contributing to Re-endothlialzation Repair after Stent Implantation”（31570948），2016.1－2019.12.
3. National Natural Science Fund of China, “The Biomechanical Mechanism of Surface Chemistry Regulating Vascular Endothelial Cell Adhesion and Migration”（31300775）, 2014.1－2016.12.
Publication：
[1] Xiaoli Wang, Bowen Xu, Mengya Xiang, Xinyue Yang, Yi Liu, Xiaoheng Liu*, Yang Shen*.Advances on Fluid Shear Stress Regulating Blood-Brain Barrier.Microvascular Res, 2019, 128:103930
[2] Guanyue Su, Hongchi Yu, Jinyong Hong, Xiaoli Wang, Tang Feng, Jiang Wu, Hongmei Yin,Yang Shen*, Xiaoheng Liu*. Integrin-Induced Signal Event Contributes to Self-Assembled Monolayers on Au-Nanoparticle-Regulated Cancer Cell Migration and Invasion.ACS Biomater Sci & Eng, 2019，5(4):1804-1821.
[3] Xiaoli Wang, Yingying Zhang, Tang Feng, Guanyue Su, Jia He，Wenbo Gao,Yang Shen*, Xiaoheng Liu*. Fluid Shear Stress Promotes Autophagy in Hepatocellular Carcinoma Cells.Int J Biol Sci, 2018, 14(10):1277-1290.
[4] Yang Shen, Bin Cao, Noah R. Snyder, Kevin M. Woeppel, James R. Eles, Xinyan Tracy Cui. ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood-brain barrier.J Nanobiotechnology. 2018, 16(1):13.
[5] Yang Shen, Min Gao, Yunlong Ma, Hongchi Yu,Fu-zhai Cui, Hans Gregersen,Qingsong Yu, Guixue Wang, Xiaoheng Liu*.Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration.Colloids Surf B Biointerfaces, 2015, 126:188-197.
[6] Yang Shen, Mengtian Leng, Hongchi Yu, Qin Zhang, Xianglin Luo, Hans Gregersen, Guixue Wang, Xiaoheng Liu*. Effect of Amphiphilic PCL-PEG Nano-micelles on HepG2 Cell Migration.Macromol Biosci, 2015, 15(3): 372-84.
[7] Yang Shen, Yunlong Ma, Min Gao, Yi Lai, Guixue Wang, Qingsong Yu, Fu-zhai Cui, Xiaoheng Liu. Integrins-FAK-Rho GTPases Pathway in Endothelial Cells Sense and Response to Surface Wettability of Plasma Nanocoatings.ACS Appl Mater Interface, 2013, 5(11):5112-5121.
[8] Yang Shen, Guixue Wang, Xianliang Huang, Qin Zhang, Jiang Wu, Chaojun Tang, Qingsong Yu, Xiaoheng Liu. Surface Wettability of Plasma SiOx:H Nanocoating Induced Endothelial Cells Migration and the Associated FAK-Rho GTPases Signaling Pathways.J R Soc Interface, 2012, 9(67):313-327.
Teaching Works：
《Induction of Biomedical Engingeering》(Undergraduate course)
《Advances on medical cytobiology》（Graduate course）
Other Information：
Standing Committee Member，Hemorheology Professional Committee of Chinese Society of Microcirculation