Name：Xiaoheng LIU
Title：Professor, Doctoral supervisor
Email：liuxiaohg@scu.edu.cn; 799174397@qq.com; Tel: 13072892510
Background：
Prof. Liureceived his PhD degree of Biomedical Engineering from Chongqing University in 1997. He engaged in postdoctoral research in West China Medical University (1997-1999). Then he went on postdoctoral research at the French National Center for Scientific Research and Université de Nancy 1 (2001-2002). In 2004, he was promoted to be a professor and doctoral supervisor. Prof. Liu served as the deputy dean in School of Medicine of Tibet University, and the director of Teaching Evaluation and Quality Supervision Office in Sichuan University. Now he is the academic leader of biomedical engineering and the director of the Committee of Professors in West China School of Basic Medical Science & Forensic Medicine, Sichuan University.
His research interest is focused on the pathogenesis of some major human diseases including malignant tumors, cardiovascular diseases, and osteoporosis. His research goal is aimed to discover relevant drug targets by exploring the physical/chemical-biological signal coupling cascade relationship and the signal transduction mechanisms. In addition, his group explores the effects of physical or chemical factors /stimuli on the underlying molecular mechanisms of cell deformation, movement, migration, F-actin reconstruction, and tissue regeneration. In recent years, he takes charge of one key program and eight general programs of the National Natural Science Foundation of China (NSFC), and more than eight provincial and ministerial-level projects. Moreover, he has published more than 130 scientific papers, obtained 5 national invention patents, as well as the first prize of Sichuan Provincial Teaching Achievement Award and the third prize forMilitary Scientific and Technological Progress of the Army.He is also selected as New Century Outstanding Talents of the Ministry of Education, outstanding experts with prominent contributions, academic and technical leaders of Sichuan Province.
Research interests：
1. Cellular physical/chemical-biological signal coupling cascade relationship and the signal transduction mechanisms:exploring the effect of physical or chemical factors/stimuli on cell deformation, movement, migration, F-actin reconstruction of vascular and tumor cells and tissue regeneration, and further exploring the underlying molecular mechanisms.
2. Pathogenesis of major age-related diseases (e.g. osteoporosis, cardiovascular and cerebrovascular diseases):exploring the molecular mechanisms of major human diseases and the effect of mechanical-chemical coupling interaction on the development and prevention of diseases.
3. Pathogenesis of tumor and its drug targets:exploring the molecular mechanisms of tumor cell migration and developing corresponding drugs according to the special molecular targets of tumor cell.
4. Tissue regeneration engineering and artificial organs:exploring the basis and application of cells and materials in the process of tissue and organ regeneration, including heart and blood vessels.
Projects：
1. National Natural Science Foundation of China, “Bone calcium loss and vascular calcium deposition in osteoporosis: mechanobiological mechanisms of matrix vesicle-mediated calcium transport” (11932014), 2020.1-2024.12.
2. National Natural Science Foundation of China, “The role of YAP signal pathway in fluid shear stress-induced epithelial-mesenchymal transition and the mechanobiological mechanisms” (31971239), 2020.1-2023.12.
3. National Natural Science Foundation of China, “A novel mechanism of fluid shear stress regulating hepatocellular carcinoma cells migration: the role and interaction of autophagy and epithelial-mesenchymal transition” (31670960), 2017.1-2020.12.
4. National Natural Science Foundation of China, “Study on mechanobiological mechanisms of fluid shear stress regulating epithelial-mesenchymal transition and migration of hepatocellular carcinoma cells” (11372203), 2014.1-2017.12.
5. National Natural Science Foundation of China, “Mechanobiological mechanisms of the interaction between hepatocellular carcinoma cells and vascular endothelial cells exposing to the mechanical-chemical microenvironment”(11172189), 2012.1-2015.12.
6. National Natural Science Foundation of China, “Cell migration related new pathway: the mechanobiological mechanisms of fluid shear stress-regulated vascular endothelial cell migration via CXCR1/2-Rho GTPases signal pathway”(10972148), 2010.1-2012.12.
7. National Natural Science Foundation of China, “Mechanical-chemical mechanisms of shear stress coupled IL-8 to regulate the permeability of vascular endothelial cells” (10772127), 2008.1-2010.12.
8. National Natural Science Foundation of China, “The mechanical-chemical coupling effect of shear stress and IL-8 induced endothelial cell migration and the underlying molecular mechanisms”(30570450), 2006.1-2008.12.
9. National Natural Science Foundation of China, “Study on the model of leukocyte adhesion to vascular wall and the biomechanical basis” (10102012), 2002.1-2004.12.
Teaching Works：
l Undergraduate course:“Introduction of Biomedical Engingeering”, “Nobel Prize and Biomedicine”
l Graduate course:“Principles and Techniques of Medical Cytobiology”, “Academic Standards and Guidance for Graduates’ Thesis Writing”, “Advances on Medical Cytobiology”, “Reading and Writing Skill of Scientific Literatures”
Selected Publications：
[21]Lili Xiong, Linlin Sun, Yixuan Zhang, Jin Peng, Junhao Yan,Xiaoheng Liu*. Exosomes from bone marrow mesenchymal stem cells can alleviate early brain injury after subarachnoid hemorrhage through miRNA129-5p-HMGB1 pathway.Stem Cells Dev, 2020, 29(4): 212-221.
[22]Guanyue Su, Hongchi Yu, Jinyong Hong, Xiaoli Wang, Tang Feng, Jiang Wu, Hongmei Yin, Yang Shen*,Xiaoheng Liu*. Integrin-induced signal event contributes to self-assembled monolayers on Au-nanoparticle-regulated cancer cell migration and invasion.ACS Biomater Sci Eng, 2019, 4(5): 1804-1821.
[23]Zhiping Yan, Guanyue Su, Wenbo Gao, Jia He, Yang Shen, Ye Zeng*,Xiaoheng Liu*. Fluid shear stress induces cell migration and invasion via activating autophagy in HepG2 cells.Cell Adh Migr, 2019, 13(1): 152-163.
[24]Ye Zeng, Jiang Wu, Xueling He, Liang Li*, Xiaojing Liu,Xiaoheng Liu*. Mechanical microenvironment regulation of age-related diseases involving degeneration of human skeletal and cardiovascular systems.Prog Biophys Mol Biol, 2019, 148: 54-59.
[25]Xiaoli Wang, Yingying Zhang, Tang Feng, Guanyue Su, Jia He, Wenbo Gao, Yang Shen*,Xiaoheng Liu*. Fluid shear stress promotes autophagy in hepatocellular carcinoma cells.Int J Biol Sci, 2018, 14(10): 1277-1290.
[26]Hongchi Yu, Min Gao, Yunlong Ma, Lijuan Wang, Yang Shen*,Xiaoheng Liu*. Inhibition of cell migration by focal adhesion kinase: Time-dependent difference in integrin-induced signaling between endothelial and hepatoblastoma cells.Int J Mol Med, 2018, 41(5): 2573-2588.
[27]Hongchi Yu, Yang Shen, Jingsi Jin, Yingying Zhang, Tang Feng,Xiaoheng Liu*. Fluid shear stress regulates HepG2 cell migration though time-dependent integrin signaling cascade,Cell Adh Migr, 2018, 12(1): 56-68.
[28]Tang Feng, Hongchi Yu, Qing Xia, Yunlong Ma, Hongmei Yin, Yang Shen*,Xiaoheng Liu*. Cross-talk mechanism between endothelial cells and hepatocellular carcinoma cells via growth factors and integrin pathway promotes tumor angiogenesis and cell migration.Oncotarget, 2017, 8(41): 69577-69593.
[29]Ye Zeng, Xing-Hong Yao, Zhi-Ping Yan, Jing-Xia Liu,Xiao-Heng Liu*. Potential signaling pathway involved in Sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer.Oncol Lett, 2016, 12(1): 379-382.
[30]Shuangfeng Liu, Fating Zhou, Yang Shen, Yingying Zhang, Hongmei Yin, Ye Zeng, Jingxia Liu, Zhiping Yan,Xiaoheng Liu*. Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells.Oncotarget, 2016, 7(22): 32876-32892.
[31]Zhiping Yan, Jingxia Liu, Linshen Xie,Xiaoheng Liu*, Ye Zeng*. Role of heparan sulfate in mediating CXCL8-induced endothelial cell migration.Peer J, 2016, 4: e1669.
[32]Ye Zeng, Xinghong Yao, Li Chen, Zhiping Yan, Jingxia Liu, Yingying Zhang, Tang Feng, Jiang Wu,Xiaoheng Liu*. Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/syndecan-1/TGF-beta autocrine loop.Oncotarget, 2016, 7(39): 63324-63337.
[33]Yang Shen, Min Gao, Yunlong Ma, Hongchi Yu, Fu-zhai Cui, Hans Gregersen,Qingsong Yu, Guixue Wang,Xiaoheng Liu*. Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration.Colloids Surf B Biointerfaces, 2015, 126: 188-197.
[34]Yang Shen, Mengtian Leng, Hongchi Yu, Qin Zhang, Xianglin Luo, Hans Gregersen, Guixue Wang,Xiaoheng Liu*. Effect of amphiphilic PCL-PEG nano-micelles on HepG2 cell migration.Macromol Biosci, 2015, 15(3): 372-384.
[35]Hongchi Yu, Yang Shen, Jinyong Hong, Qing Xia, Fating Zhou,Xiaoheng Liu*. The contribution of TGF-β in epithelial-mesenchymal transition (EMT): down-regulation of E-cadherin via snail.Neoplasma, 2015, 62(1): 1-15.
[36]Ye Zeng, Xing-Hong Yao,Xiaoheng Liu*. Numerical simulation of the effect of permeability on the hydrodynamics in a parallel-plate coculture flow chamber.Comput Method Biomec, 2014, 17(8): 875-887.
[37]Hongchi Yu, Xianliang Huang, Yunlong Ma, Min Gao, Ou Wang, Ting Gao, Yang Shen*,Xiaoheng Liu*. Interleukin-8 regulates endothelial permeability by down-regulation of tight Junction but not dependent on Integrins induced focal adhesions.Int J Biol Sci, 2013, 9(9): 966-979.
[38]Xianliang Huang, Yang Shen, Yi Zhang, Lin Wei, Yi Lai, Jiang Wu, XiaojingLiu,Xiaoheng Liu*. Rac1 mediates laminar shear stress-induced vascular endothelial cell migration.Cell Adh Migr, 2013, 7(6): 462-468.
[39]Yang Shen, Yunlong Ma, Min Gao, Yi Lai, Guixue Wang, Qingsong Yu, Fu-zhai Cui,Xiaoheng Liu*. Integrins-FAK-Rho GTPases pathway in endothelial cells sense and response to surface wettability of plasma nanocoatings.ACS Appl Mater Inter,2013, 5: 5112−5121.
[40]Yang Shen, Guixue Wang, Xianliang Huang, Qin Zhang, Jiang Wu, Chaojun Tang, Qingsong Yu,Xiaoheng Liu*. Surface wettability of plasma SiOx:H nanocoating induced endothelial cells migration and the associated FAK－Rho GTPases signaling pathways.J R Soc Interface,2012, 9(67): 313-327.
Other Information：
● Committee member, Professional Committee on Biomechanics of Chinese Society of Mechanics/Chinese Society of Biomedical Engineering. Standing committee member, Hemorheology Professional Committee of Chinese Society of Physiology. Committee member, Professional Committee on Mechanical Biology of Chinese Society for Biomaterials. Member of International Society for Biomaterials and World Association for Chinese Biomedical Engineers.
● Editorial board member ofJournal of Biomedical EngineeringandHans Journal of Biomedicine. Assessment expert of National Natural Science Prize and National Natural Science Foundation of China. Reviewer ofBiophysical Journal,Journal of Biomechanics,Chinese Journal of Biomedical EngineeringandJournal of Biomedical Engineering.
Curriculum Vitae
Name：Xiaoheng Liu
Title：Professor, Doctoral supervisor
Email:liuxiaohg@scu.edu.cn
Background：
Prof. Xiaoheng Liu, graduated from Chongqing University in 1997 with a PhD, majoring in biomedical engineering. From 1997 to 1999, he was engaged in postdoctoral research in West China Medical University, and then worked on the teaching and research of biomedical engineering. From 2001 to 2002, he studied at the French National Scientific Research Centre as a visiting scholar. In 2004, he was promoted to be a professor, and now he is the academic leader of biomedical engineering and the chair of the Academic Committee in West China school of basic medical science & forensic medicine, Sichuan University.
Prof. Liu always focuses on the research of cell biomechanics and rheology, and have did a lot of innovative works on endothelial cell adhesion, migration, skeletal remodeling and tumor cell metastasis. In recent years, he has presided 9 projects from the National Natural Science Foundation of China (NSFC) and 3 projects from provincial and ministerial-level funds. Meanwhile, he completed 9 cooperative research projects, including key projects and general projects of the NSFC, “863” and “973” projects of the Ministry of Science and Technology. He has published more than 130 papers, including about 55 SCI papers and 77 Chinese core journal papers. Additionally, Prof. Liu obtained 3 national invention patents and 1 third prize for scientific and technological progress. He was selected as academic and technical leaders of Sichuan Provincial Department of Health, Academic leaders of Sichuan Outstanding Youth, New Century Outstanding Talents of The Ministry of Education, and Outstanding experts with prominent contributions.
Prof. Liu paid much attention to the combination of innovation and practicality of scientific research. He firstly proposed the compound drop model and the coupling model of cell and blood flow interaction to describe the rheological characteristics of cells. The theory attracted much attention from international colleagues and make a great influence in the field of biomedical engineering. Recently, his team keeps working on cell and tissue biomechanics, tumor cell migration and invasion, tissue and cell regeneration, artificial organs, biomedical signal detection, which have important theoretical significance and potential application prospects. Moreover, his lab has established good cooperative relationships with international counterparts (e.g. the United States, France and the United Kingdom) and domestic counterparts (e.g. Institute of Mechanics of the Chinese Academy of Sciences, Chongqing University and Wuhan University).
Research interests：
5. Biomechanics and engineering of tissue and cell and the clinical application
6. Tumor microenvironment and tumor cell migration
7. Tissue regeneration engineering and artificial organs
8. Mechanisms on cardiovascular diseases
Projects：
10. National Natural Science Foundation of China, “Bone calcium loss and vascular calcium deposition in osteoporosis: mechanobiological mechanisms of matrix vesicle-mediated calcium transport” (11932014), 2020.1-2024.12.
11. National Natural Science Foundation of China, “The role of YAP signal pathway in fluid shear stress-induced epithelial-mesenchymal transition and the mechanobiological mechanisms” (31971239), 2020.1-2023.12.
12. National Natural Science Foundation of China, “A novel mechanism of fluid shear stress regulating hepatocellular carcinoma cells migration: the role and interaction of autophagy and epithelial-mesenchymal transition” (31670960), 2017.1-2020.12.
13. National Natural Science Foundation of China, “Study on mechanobiological mechanisms of fluid shear stress regulating epithelial-mesenchymal transition and migration of hepatocellular carcinoma cells” (11372203), 2014.1-2017.12.
14. National Natural Science Foundation of China, “Mechanobiological mechanisms of the interaction between hepatocellular carcinoma cells and vascular endothelial cells exposing to the mechanical-chemical microenvironment”(11172189), 2012.1-2015.12.
15. National Natural Science Foundation of China, “Cell migration related new pathway: the mechanobiological mechanisms of fluid shear stress-regulated vascular endothelial cell migration via CXCR1/2-Rho GTPases signal pathway”(10972148), 2010.1-2012.12.
16. National Natural Science Foundation of China, “Mechanical-chemical mechanisms of shear stress coupled IL-8 to regulate the permeability of vascular endothelial cells” (10772127), 2008.1-2010.12.
17. National Natural Science Foundation of China, “The mechanical-chemical coupling effect of shear stress and IL-8 induced endothelial cell migration and the underlying molecular mechanisms”(30570450), 2006.1-2008.12.
18. National Natural Science Foundation of China, “Study on the model of leukocyte adhesion to vascular wall and the biomechanical basis” (10102012), 2002.1-2004.12.
Publications：
[1] Xiaoli Wang, Bowen Xu, Mengya Xiang, Xinyue Yang, Yi Liu,Xiaoheng Liu*, Yang Shen*. Advances on fluid shear stress regulating blood-brain barrier.Microvasc Res, 2020, 128: 103930.
[2] Lili Xiong, Linlin Sun, Yixuan Zhang, Jin Peng, Junhao Yan,Xiaoheng Liu*. Exosomes from bone marrow mesenchymal stem cells can alleviate early brain injury after subarachnoid hemorrhage through miRNA129-5p-HMGB1 pathway.Stem Cells Dev, 2020, 29(4): 212-221.
[3] Guanyue Su, Hongchi Yu, Jinyong Hong, Xiaoli Wang, Tang Feng, Jiang Wu, Hongmei Yin, Yang Shen*,Xiaoheng Liu*. Integrin-induced signal event contributes to self-assembled monolayers on Au-nanoparticle-regulated cancer cell migration and invasion.ACS Biomater Sci Eng, 2019, 4(5): 1804-1821.
[4] Zhiping Yan, Guanyue Su, Wenbo Gao, Jia He, Yang Shen, Ye Zeng*,Xiaoheng Liu*. Fluid shear stress induces cell migration and invasion via activating autophagy in HepG2 cells.Cell Adh Migr, 2019, 13(1): 152-163.
[5] Ye Zeng, Jiang Wu, Xueling He, Liang Li*, Xiaojing Liu,Xiaoheng Liu*. Mechanical microenvironment regulation of age-related diseases involving degeneration of human skeletal and cardiovascular systems.Prog Biophys Mol Biol, 2019, 148: 54-59.
[6] Xiaoli Wang, Yingying Zhang, Tang Feng, Guanyue Su, Jia He, Wenbo Gao, Yang Shen*,Xiaoheng Liu*. Fluid shear stress promotes autophagy in hepatocellular carcinoma cells.Int J Biol Sci, 2018, 14(10): 1277-1290.
[7] Hongchi Yu, Min Gao, Yunlong Ma, Lijuan Wang, Yang Shen*,Xiaoheng Liu*. Inhibition of cell migration by focal adhesion kinase: Time-dependent difference in integrin-induced signaling between endothelial and hepatoblastoma cells.Int J Mol Med, 2018, 41(5): 2573-2588.
[8] Hongchi Yu, Yang Shen, Jingsi Jin, Yingying Zhang, Tang Feng,Xiaoheng Liu*. Fluid shear stress regulates HepG2 cell migration though time-dependent integrin signaling cascade,Cell Adh Migr, 2018, 12(1): 56-68.
[9] Tang Feng, Hongchi Yu, Qing Xia, Yunlong Ma, Hongmei Yin, Yang Shen*,Xiaoheng Liu*. Cross-talk mechanism between endothelial cells and hepatocellular carcinoma cells via growth factors and integrin pathway promotes tumor angiogenesis and cell migration.Oncotarget, 2017, 8(41): 69577-69593.
[10]Shuangfeng Liu, Fating Zhou, Yang Shen, Yingying Zhang, Hongmei Yin, Ye Zeng, Jingxia Liu, Zhiping Yan,Xiaoheng Liu*. Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells.Oncotarget, 2016, 7(22): 32876-32892.
[11]Zhiping Yan, Jingxia Liu, Linshen Xie,Xiaoheng Liu*, Ye Zeng*. Role of heparan sulfate in mediating CXCL8-induced endothelial cell migration. Peer J, 2016, 4: e1669.
[12]Ye Zeng*, Xinghong Yao, Li Chen, Zhiping Yan, Jingxia Liu, Yingying Zhang, Tang Feng, Jiang Wu,Xiaoheng Liu*. Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/syndecan-1/TGF-beta autocrine loop.Oncotarget, 2016, 7(39): 63324-63337.
[13]Yang Shen, Min Gao, Yunlong Ma, Hongchi Yu, Fu-zhai Cui, Hans Gregersen,Qingsong Yu, Guixue Wang,Xiaoheng Liu*. Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration.Colloids Surf B Biointerfaces, 2015, 126:188-197.
[14]Yang Shen, Mengtian Leng, Hongchi Yu, Qin Zhang, Xianglin Luo, Hans Gregersen, Guixue Wang,Xiaoheng Liu*. Effect of amphiphilic PCL-PEG nano-micelles on HepG2 cell migration.Macromol Biosci, 2015, 15(3): 372-384.
Other Information：
● Standing Committee Member, Hemorheology Professional Committee of Chinese Society of Physiology;
● Member of International Society for Biomaterials and World Association for Chinese Biomedical Engineers;
● Editorial board member of Journal of Biomedical Engineering;
● Assessment expert of National Natural Science Prize and National Natural Science Foundation of China;
● Reviewer of Biophysical Journal, Journal of Biomechanics, Journal of Biomedical EngineeringandChinese Journal of Biomedical Engineering.