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Lihong WAN

Post time:2020-06-02 Viewed:


M.D., Ph.D, Associate professor

Department of Pharmacology, West China School of Basic Medical Sciences &Forensic Medicine, Sichuan University

Address: Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Sichuan Province, Chengdu, 610041, P. R. China



Dr. Wan main research interests lie in the study of understanding the mechanism of drug addiction, neurodegenerative disease and airway remodeling disease. The focus of Dr. Wan’s research program is to define the role of RACK1 in drug addiction, neurodegenerative disease and airway remodeling disease. The ongoing research project is: The bidirectional regulation mechanism of RACK1 on bronchial epithelial cell damage repair process of airway remodeling in asthma and the intervention effect of macrolides. This project is supported by National Natural Science Foundation of China. Dr. Wan has published 70 refereed papers, including 22 SCI papers; 16 papers by the first author (correspondent) SCI.

Education and Training

West China University of Medical Sciences MD, Medicine 2000

Sichuan University MS, Pharmacology 2005

Sichuan University Ph.D, Chronobiology 2009

Molecular biology medical center, Kantonsspital Aarau, Switherland, Visiting scholar 2003

NIH, Visiting scholar 2015

Area of Interest

Drug addiction; Neurodegenerative disease; Asthma; Cell signal

Selected Publication

1. Wan L, Su L, Xie Y, Liu Y, Wang Y, Wang Z. Protein receptor for activated C kinase 1 is involved in morphine reward in mice.Neuroscience, 2009, 161(3): 734-42.

2. Wan Lihong, Wang Zhengrong, Zhou Liming. Protecting Effects of Emodin on Multiorgan Failure of Rats With Severe Acute Pancreatitis. Pancreas, 2009, 38(7): 835-836.

3. Wan LH, Chen J, Li L, Xiong WB, Zhou LM. Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats.Pharm Biol, 2011, 49(11): 1204-1209.

4. Wan L, Xie Y, Su L, Liu Y, Wang Y, Wang Z. RACK1 affects morphine reward via BDNF.Brain Res,2011, 1416: 26-34.

5. Zhou Y, Tan X, Kuang W, Liu L, Wan L*. Erythromycin ameliorates cigarette-smoke–induced emphysema and inflammation in rats.Transl Res, 2012, 59(6): 464-472.

6. Li LK, Kuang WJ, Huang YF, Xie HH, Chen G, Zhou QC, Wang BR, Wan LH*. Anti-tumor effects of Astragalus on hepatocellular carcinoma in vivo.Indian J harmacol, 2012, 44(1): 78-81.

7. Wu YY, Wan LH, Zheng XW, Shao ZJ, Chen J, Chen XJ, Liu LT, Kuang WJ, Tan XS, hou LM. Inhibitory Effects of β,β-Dimethylacrylshikonin on Hepatocellular arcinoma In Vitro and In Vivo.Phytother Res, 2012, 26(5):764-71.

8. L. Wan, L. Liu, Z. Zhang, Y. Zhou, Y. Xiong, D. Li and L. Zhou. Low-dose azithromycin attenuates OVA-induced airway remodeling and inflammation via down-regulating TGF-β1 expression in rat.Euro J Inflam, 2013, 1(1): 133-145.

9. Liu LT*, Wan LH*, Song XH, Xiong Y, Jin SJ, Zhou LM. Relevance of class 1 integrons and extended‑spectrum β‑lactamases in drug‑resistant Escherichia coli.Mol Med Rep, 2013, 8(4):1251-5.

10 Teng Y, Zhang MQ, Wang W, Liu LT, Zhou LM, Miao SK, Wan LH*. Compound danshen tablet ameliorated abeta25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins.BMC Complement Altern Med, 2014, 14(1): 23.

12. Liu L, Zhu J, Zhou L, Wan L*. Alcohol-induced reward memory is positively associated with persistent high levels of RACK1, LC3-II/I and synaptophysin in hippocampus of C57BL/6J mice.J NEUROL SCI-TURK,2015, 32(4):718-727.

13. Zhou Y, Liao S, Zhang Z, Wang B, Wan L*. RACK1 promotes maintenance of morphine-associated memory via activation of an ERK-CREB dependent pathway in hippocampus.Sci Rep, 2016 Feb 2, 6: 20183.

14. Zhu J, Chen X, Song Y, Zhang Y, Zhou L, Wan L*. Astragalus injection attenuates bleomycin-induced pulmonary fibrosis via down-regulating Jagged1/Notch1 in lungs.J Pharm Pharmacol, 2016 Mar; 68(3): 389-96.

15. Zhu J, Liao S, Zhou L, Wan L*. Deficit of RACK1 contribute to the spatial memory impairment via up regulating BECLIN1 to induce autophagy.Life Sci, 2016 Apr 15; 151: 115-21.

16. Liu Y, Pu Y, Li D, Zhou L, Wan L*. Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis.Life Sci, 2017 Feb 1; 170: 1-8.

17. Tanshinone IIA attenuates Aβ25-35-induced spatial memory impairment via upregulating receptors for activated C kinase1 and inhibiting autophagy in hippocampus.J Pharm Pharmacol, 2017 Feb; 69(2): 191-201.