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Xiaodong SUN

Post time:2020-06-02 Viewed:


Associate Investigator

Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University



SUN Xiaodong’s current research interests focus on understanding the cellular metabolism and diseases and the pharmacological research of related drugs including following research areas: (1) Intracellular vesicle fate and autophagy; (2) Cytoskeleton and intracellular vesicle trafficking; (3) Pharmacological mechanism of cellular energy metabolism drugs


Sept. 2010 - Jun. 2013: Ph.D. in Cell Biology, College of Life Sciences, Nankai

University, China.

Sept. 2007 - Jun. 2010: M.S. in Genetics, College of Life Sciences, Nankai University,


Sept. 2000 - Jun. 2004: B.S. in Biological Technology, College of Life Sciences, Nankai University, China.


Mar. 2015 - now: Associate investigator at Sichuan University

Dec. 2013 - Dec. 2014: Postdoctoral fellow, Department of Biomedical Engineering at

Georgia Institute of Technology & Emory University School of Medicine.

Jul. 2004 - Jun. 2010: Staff, College of Life Sciences, Nankai University, China.

Sep. 2005, assistant tutor at Nankai University

Dec 2009, instructor at Nankai University


(1) Medical Cell Biology

(2) Pharmacology


1) Sun Q*, Yong X* SunX*, Yang F*, Dai Z, Gong Y, Zhou L, Zhang X, Niu D, Dai L, Liu J, Jia D. (2017) Structural and functional insights into sorting nexin 5/6 interaction with bacterial effector IncE.Signal Transduction and Targeted Therapy 2: e17030

2) Yang Y*, Ran J*, Sun L*, Sun X*, Luo Y, Yan B, Tala, Liu M, Li D, Zhang L, Bao G, Zhou, J. (2015) Cyld regulates noscapine activity in acute lymphoblastic leukemia via a microtubule-dependent mechanism.Theranostics 5(7): 656-666.

3) Tala*, Xie S*, Sun X*, Sun X, Ran J, Zhang L, Li D, Liu M, Bao G, Zhou J. (2014) Microtubule-associated protein mdp3 promotes breast cancer growth and metastasis.Theranostics 4(10): 1052-1061.

4) Li D*, Sun X*, Zhang L, Yan B, Xie S, Liu R, Liu M, Zhou J. (2014) Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells.Protein & Cell. 5(3): 214-223.

5) Liu M, Li D, Sun L, Chen J, Sun X, Zhang L, Huo L, Zhou J. (2014) Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat-mediated apoptosis in CD4-positive T-lymphocytes.Journal of Pathology 233(2): 138-147.

6) Sun L, Sun X, Xie S, Yu H, Zhong D. (2014) Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation.Biochemical and biophysical research communications 447(3): 465-470.

7) Xie S, Dong B, Sun X, Tala, He X, Zhou J, Liu M, Li D. (2014) Identification of a cytoplasmic linker protein as a potential target for neovascularization.Atherosclerosis 233(2): 403-409.

8) Sun X*, Liu M*, Hao J*, Li D, Luo Y, Wang X, Yang Y, Li F, Shui W, Chen Q, Zhou J. (2013) Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.Cell Cycle 12(7): 1133-1141.

9) Sun X, Li F, Dong B, Suo S, Liu M, Li D, Zhou J. (2013) Regulation of tumor angiogenesis by the microtubule-binding protein CLIP-170.Protein & Cell 4(4): 266-276.

10) Zhang C, Sun X, Ren Y, Lou Y, Zhou J, Liu M, Li D. (2012) Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells.Cancer Biology & Therapy 13(12): 1214-1220.

11) Sun X*, Li D*, Yang Y*, Ren Y, Li J, Wang Z, Dong B, Liu M, Zhou J. (2012) Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity.Journal of Pathology 226(4): 666-673.

12) Peng G, Ren Y, Sun X, Zhou J, Li D. (2012) Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration.Biochemical Pharmacology 83(10): 1374-1382.

13) Li J*, Sun X*, Wang Z, Chen L, Li D, Zhou J, Liu M. (2012) Regulation of vascular endothelial cell polarization and migration by Hsp70/Hsp90-organizing protein.PLoS One 7(4): e36389.

14) Sun X D*, Shi X J*, Sun X O*, Luo Y G, Wu X J, Yao C F, Yu H Y, Li D W, Liu M,Zhou J. (2011) Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5.Acta Pharmacologica Sinica 32(12): 1543-1548.

15) Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong J T, Li M, Joshi H C,Zhou J.(2008) Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase.Journal of Biological Chemistry 283(51): 35783-35788.