Jianguo QI, Medical PhD, Professor, PhD supervisor
Department of Histology and Embryology and Neurobiology, West China School of Basic Medicine and Forensic Medicine, Sichuan University
Admissions discipline:
1. Human anatomy and histology and embryology
Research direction: neuro-immune interaction
2. Medical Neurobiology
Research direction: Immunological mechanism of neuropathic pain
Contact address:
West China Campus of Sichuan University, No.17, Section 3, Renmin South Road, Wuhou District, Chengdu, Sichuan Province; Postcode: 610041
Mobile: + 86-13678161688
Email:jgqi@scu.edu.cn
Research Introduction:
Professor Qi is mainly interested in understanding the neuroimmunological dialogue between the immune system and the nervous system during neurodevelopment and disease states from the anatomical, cellular and molecular levels.
The research group led by Professor Qi, NIRVANA (NeuroImmunology Research Van & the AntLab) Research Group, focuses on analyzing the susceptibility of damaged nervous system regeneration and chronic pain & itching and the molecular mechanism of pathogenesis from the perspective of neuroimmunology.
The current research topics of this research group are as follows:①The role and mechanism of T cells in the process of chronic pain and itching caused by nerve injury;②Cells of neuronal activity-dependent aseptic neuroinflammation in chronic pain and itching Molecular mechanism and pathological significance;③The role and mechanism of maternal immune activation and postnatal immune stimulation in the susceptibility to chronic pain and itching;④The therapeutic application of worm-derived immunomodulatory molecules to nerve regeneration and chronic pain and itching⑤The role and mechanism of the immune system in peripheral nerve regeneration;⑥Technological innovation of high-resolution three-dimensional microscopic imaging and in situ quantitative biology.
Professor Qi has published 66 papers in professional academic journals, including 21 papers in SCI; 2 monographs. Representative papers have been published in Gene Thereapy, Cytotherapy, Cellular and Molecular Neurobiology, Reviews in theNeurosciences, BioTechniques, Neuroreport, Journal of Neuroinflammation and other journals.
Professor Qi is currently a member of the Professional Committee of Neuroanatomy and the Professional Committee of Histology and Embryology of the Chinese Society of Anatomy. Hosted 1 National Natural Science Foundation Project (31571240), 1 Science and Technology Support Project of Sichuan Provincial Science and Technology Department (2013SZ0069), 1 Applied Basic Research Project of Sichuan Provincial Science and Technology Department (2010JY0057), 1 National Natural Science Foundation Youth Fund (39100040), 2 projects of Sichuan Provincial Development and Regeneration Key Laboratory (SYS13-001, SYS17-007).
Education:
● 1997-2000 Iowa State University Institute of Human Gene Therapy & Stoddard Cancer Institute, postdoctoral
● 1996-1997 New Zealand University of Auckland School of Medicine, postdoctoral
● 1983-1989 West China Medical University School of Basic Medicine, Medical PhD
● 1978-1982 Sichuan Medical College, Bachelor of Medicine
Research areas:
Neuroimmunology; glial cells; nerve regeneration; pathological pain & itch; maternal immune activation; neural development; immunotherapy; high-resolution three-dimensional microscopic imaging; in situ quantitative biology
Representative papers:
1．Du B,Ding YQ,Xiao X,Ren HY,Su BY,Qi JG.CD4+αβT cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries.J Neuroinflammation,2018; 15: 81; doi:10.1186/s12974-018-1115-7.
2．Ding YQ, Xie WZ,Qi JG. Regenerative peripheral neuropathic pain: novel pathological pain, new therapeutic dimension.Rev Neurosci. 2017;28(1):65-76.
3．Xiao X,Feng YP, Du B, Sun HR,Ding YQ,Qi JG.Antibody incubation at37℃improves fluorescentimmunolabellingin free-floating thick tissue sections.Bio Techniques. 2017; 62(3): 115-122.
4．Ding YQ, Li XY, Xia GN, Ren HY, Zhou XF, Su BY,Qi JG. ProBDNF inhibits collective migration and chemotaxis of rat Schwann cells.Tissue Cell. 2016;48(5):503-510.
5．Ren HY, Ding YQ, Xiao X, Xie WZ, Feng YP, Li XY,Qi JG.Behavioral characterization of neuropathic pain on the glabrous skin areas reinnervated solely by axotomy-regenerative axons after adult rat sciatic nerve crush.Neuroreport.2016;27(6):404-414.
6．Tong LL, Ding YQ, Jing HB, Li XY,Qi JG.Differential motor and sensory functional recovery in male but not female adult rats is associated with remyelination rather than axon regeneration after sciatic nerve crush.Neuroreport. 2015;26(7):429-437.
7．Wang YC, Xia QJ, Ba YC, Wang TY, Li N, Zou Y, Shang FF, Zhou XF, Wang TH, Fu XM,Qi JG.Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad.Cytotherapy.2014; 16(7):1000-1010.
8．Xia GN,Zou Y,Wang YC,Xia QJ,Lu BT,Wang TH,Qi JG.Neural stem cells grafts decrease neural apoptosis associated with caspase-7 downregulation and BDNF upregulation in rats following spinal cord hemisection.Cell Mol Neurobiol.2013;33(7):1013-1022.
9．Qi J, Shackelford R, Manuszak R, Cheng D, Smith M, Link CJ, Wang S. Functional expression of ATM gene carried by HSV amplicon vectorin vitroandin vivo.Gene Ther. 2004; 11(1): 25-33.
10．Qi J, Link CJ Jr, Wang S. Direct observation of GFP gene expression transduced with HSV-1 /EBV amplicon vector in unfixed tumor tissue.Bio Techniques. 2000;28(2): 206-208.