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Hua ZHOU, Ph.D.


Department of Physiology

West China School of Basic Medical Sciences & Forensic Medicine

Sichuan University


Room 414, Yifu building

No.17 People's South Road,Chengdu,610041

Phone Number:86-28-85503048

Fax Number:86-28-85503204


Dr. Zhou main research interests lie in the study of neuronal excitability and network synchronization within the mammalian central nervous system. Using EEG recording invivoand whole-cell ion currents recording on acute isolated hippocamal neurons and on hippocampal slices invitro, she investigated channel mechanisms of epileptogenesis in Tutin (a chemical convulsant derived from Chinese herbs) induced epileptic rats. Another study is to explore the protective mechanism of neuroprotective agents on ischemic neurons. she has been participating in research works of the National Natural Science Funds and Doctoral Funds of Ministry of Education.

She went to the University of Hong Kong, and Brigham and Women 's Hospital affiliated to Harvard Medical School for academic research and interview. She has published more than 20 papers in the international and domestic academic journals. She serves as a member of Chinese society of physiology, specialized committee of respiratory physiology, and the secretary and a memberofphysiology specialized committee of Sichuan provincial physiological science society.

Education and Training

1. Xi’an Medical University in 1987, Bachelor’s degree in medicine

2. West China University of Medical Sciences in 1997, Master’s degree in medicine

3. Sichuan University in 2005, Ph.D.

degree from She is a professor of physiology at Sichuan University. In the field of teaching, she has long been engaged in the teaching of undergraduate and graduate students for a long time and won many awardsfor educational reform projects and teaching achievements.

Area of Interest

Neurobiology, Neuroelectrophysiology, Cell Apoptosis, Cell Signing

Selected Publications

1. Li H, Chen L, Hou XF,Zhou H, Zheng Y.Hydrogen sulfide attenuates hypoxia-induced respiratory suppression in anesthetized adult rats.Respiratory Physiology & Neurobiology.220:1-9, 2016.

2. Ding Y, Hou XF, Chen L,Zhou H, Gong YJ, Dai LQ, Zheng Y*. Heme oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic injury on medulla oblongata in rats.Journal of the Neurological Sciences. 361:101-111, 2016.

3. Lei F, Yan X, Zhao FS, Zhang SF, Zhang QL,Zhou H, Zheng Y. Impairment of central chemoreception in neonatal rats induced by maternal cigarette smoke exposure during pregnancy.PLOS ONE, DOI: 10.1371/journal. pone. 0137362, 2015.

4. Zhou H,Wang J, Jiang JY, Stavrovskaya IG, Li MC, Li W, Wu QF, Zhang XM, Luo CL, Zhou SH, Sirianni AC, Sarkar S, Kristal BS, Friedlander RM, Wang X. N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury.The Journal of Neuroscience. 34(8): 2967-2978, 2014.

5. Li H, Hou XF, Ding Y, Nie LH,Zhou H, Nie Z, Tang YH, Chen L, Zheng Y. Effects of H2S on the central regulation of respiration in adult rats.Neuroreport. 25:358-366,2014.

6. Ding Y, Hou XF, Chen L, Li H, Tang YH,Zhou H, Zhao S, Zheng Y. Protective action of Tetramethylpyrazine on medulla oblongata in rats with chronic hypoxia.Autonomic Neuroscience: Basic and Clinical. 173:45-52, 2013.

7. Li MQ, Nie LH, Hu YJ, Yan X, Xue L, Chen L,Zhou H, Zheng Y. Chronic intermittent hypoxia promotes expression of 3-mercaptopyruvate sulfurtransferase in adult rat medulla oblongata.Autonomic Neuroscience: Basic and Clinical. 179:84-89, 2013.

8. Chen L, Zhang J, Ding Y, Li H, Nie LH,Zhou H, Tang YH, Zheng Y. Site-specific hydrogen sulfide-mediated central regulation of respiratory rhythm in medullary slices of neonatal rats.Neuroscience. 233:118-126, 2013.

9. Chen L, Zhang J, Ding Y, Li H, Nie LH, Yan X,Zhou H, Zheng Y*. KATP channels of parafacial respiratory group (pFRG) neurons are involved in H2S-mediated central inhibition of respiratory rhythm in medullary slices of neonatal rats.Brain Research. 1527:141-148, 2013.

10. Nie LH, Hu YJ, Yan X, Li MQ, Chen L, Li H, Li X,Zhou H, Zheng Y. The anti-apoptotic effect of hydrogen sulfide attenuates injuries to the medullary respiratory centers of neonatal rats subjected to in utero cigarette smoke exposure.Respiratory Physiology & Neurobiology. 188:29-38, 2013.

11. Chen L, Zhang J, He Y, Pan JG,Zhou H, Li H, Tang YH, Zheng Y. Contribution of BKCa channels of neurons in rostral ventrolateral medulla to CO-mediated central regulation of respiratory rhythm in medullary slices of neonatal rats.Respiratory Physiology & Neurobiology. 182:93–99, 2012.

12. Pandya RS, Mao LJ,Zhou H, Zhou SH, Zeng J, Popp AJ, Wang X. Central Nervous System Agents for Ischemic Stroke: Neuroprotection Mechanisms.Central Nervous System Agents in Medicinal Chemistry. 2011; 11(2): 81–97

13. Zhang J, He Y, Ding Y,Zhou H, Tang YH, Chen L, Zheng Y. Nitric oxide synthase expression in the medullary respiratory related nuclei and its involvement in CO-mediated central respiratory effects in neonatal rats.Brain Research Bulletin. 84:258–263, 2011.

14. Pan JG, Zhang J,Zhou H, Chen L, Tang YH, Zheng Y*.Protective action of endogenously generated H2S on hypoxia-induced respiratory suppression and its relation to antioxidation and down-regulation of c-fos mRNA in medullary slices of neonatal rats.Respiratory Physiology & Neurobiology. 178:230–234, 2011.

15. Pan JG, Hu HY, Zhang J,Zhou H, Chen L, Tang YH, Zheng Y*. Protective effect of hydrogen sulfide on hypoxic respiratory suppression in medullary slice of neonatal rats.Respiratory Physiology & Neurobiology. 171:181-186, 2010.

16. Zhang J, Chen L, He Y, Ding Y,Zhou H, Hu HY, Tang YH, Zheng Y. Large-conductance calcium-activated potassium channels in the neurons of pre-Bötzinger complex and their participation in the regulation of central respiratory activity in neonatal rats.Neuroscience Letters. 481:159-163, 2010.