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Dr. Kui WANG,Associate Research Fellow


➢ Education and Professional Experience

2018/03–present Associate Research Fellow, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, P.R. China

2015/07–2018/02 Postdoctoral Fellow, Assistant Research Fellow, lab of Prof. Yuquan Wei and Prof. Canhua Huang, West China Hospital, Sichuan University, Chengdu, P.R. China

2013/01–2014/01 Visiting Scholar, lab of Prof. Edouard Nice, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

2010/09–2015/06 Ph.D. student, lab of Prof. Canhua Huang, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, P.R. China

2006/09–2010/07 B.Sc, College of Life Science, Sichuan University, Chengdu, P.R.China

➢ Research Interest

1. Redox signaling, metabolism and autophagy in cancer

2. Chemical proteomics identifying drug targets

➢ Editorial Board

Expert Rev Proteomics(2019 --)

➢ Manuscript Reviewing

I have reviewed papers for international Journals including Mol Cancer, Theranostics, Cancer Lett, Signal Transduct Target Ther.

➢ Publications (*co-first author; # co-corresponding author)

I have published 20 papers as first/co-first or co-corresponding author in Trends Biochem Sci (IF:16.89),Hepatology (IF:14.97),Autophagy (IF:14.97, 4 publications)、Cancer Res (IF:9.12)、Med Res Rev (IF: 9.79) etc. These publications have been cited by Cell, Nat Rev Drug Discov or Nat Rev Microbiol for over 1400 times. Among them, 2 publications have reached over 180 citations, the highest citation is 244.

1. Wang K, Jiang J, Lei Y, Zhou S, Wei Y, Huang C. Targeting Metabolic-Redox Circuits for Cancer Therapy.Trends Biochem Sci. 2019;44(5):401-14. (IF: 16.89)

2. Jiang J, Zhang L, Chen H, Lei Y, Zhang T, Wang Y, Jin P, Lan J, Zhou L, Huang Z, Li B, Liu Y, Gao W, Xie K, Zhou L, Nice EC, Peng Y, Cao Y, Wei Y, Wang K#, Huang C#. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.Autophagy. 2020;16(1):106-22. (IF: 11.06; co-corresponding author)

3. Huang Z*, Zhou JK*, Wang K*, Chen H, Qin S, Liu J, Luo M, Chen Y, Jiang J, Zhou L, Zhu L, He J, Li J, Pu W, Gong Y, Li J, Ye Q, Dong D, Hu H, Zhou Z, Dai L, Wei Y, Huang C, Wei X, Peng Y. PDLIM1 inhibits tumor metastasis through activating Hippo signaling in hepatocellular carcinoma.Hepatology. 2020; doi: 10.1002/hep.30930. (IF: 14.97; co-first author).

4. Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, Huang C, Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling.Autophagy. 2011;7(9):966-78. (IF: 11.06; 244 citations)

5. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Nice EC, Wu M, Huang C, Wei Y. Identification of ANXA2 (annexin A2) as a Specific Bleomycin Target to Induce Pulmonary Fibrosis by Impeding TFEB-mediated Autophagic Flux.Autophagy. 2018;14(2):269-82. (IF: 11.06)

6. Lei Y*, Wang K*, Li X*, Li Y, Feng X, Zhou J, Zhang Z, Huang C, Zhang T. Cell-surface Translocation of Annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice.Clin Sci. 2019;133(7):789-804. (IF: 5.24; co-first author)

7. Wang K, Chen Y, Zhang P, Lin P, Xie N, Wu M. Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases.Cells. 2019;8(2). pii: E123. (IF: 5.66)

8. Wang K, Gao W, Dou Q, Chen H, Li Q, Nice EC, Huang C. Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer.Autophagy.2016;12(12):2498-9. (IF: 11.06)

9. Dou Q*, Chen HN*, Wang K*, Yuan K*, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, Zhang L, Xiang R, Nice EC, Wei Y, Huang C. Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer.Cancer Res. 2016;76(15):4457-69. (IF: 9.12; co-first author)

10. Wang K, Zhang T, Dong Q, Nice EC, Huang C, Wei Y. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation.Cell Death Dis. 2013;14;4:e537.(IF: 5.96; 186 citations)

11. Lei Y*, Wang K*, Deng L*, Chen Y, Nice EC, Huang C. Redox Regulation of Inflammation: Old Elements, a New Story.Med Res Rev. 2015;35(2):306-40. (IF: 9.79; co-first author)

12. Jiang J*, Wang K*, Chen Y*, Chen H, Nice EC, Huang C. Redox regulation in tumor cell epithelial-mesenchymal transition: Molecular basis and therapeutic strategy.Signal Transduct Target Ther. 2017;2:e17036. (IF: 5.87, co-first author)

13. Zhang L*, Wang K*, Lei Y, Li Q, Nice EC, Huang C. Redox signaling: Potential arbitrator of autophagy and apoptosis in therapeutic response.Free Radic Biol Med.2015;89:452-65. (IF: 5.66; co-first author)

14. Ren F*, Wang K*, Zhang T, Jiang J, Nice EC, Huang C. New insights into redox regulation of stem cell self-renewal and differentiation.BBA-Gen Subjects. 2015;1850(8):1518-26. (IF: 3.68; co-first author)

15. Wang K, Huang C, Nice EC. Proteomics, genomics and transcriptomics: their emerging roles in the discovery and validation of colorectal cancer biomarkers.Expert Rev Proteomics. 2014;11(2):179-205. (IF: 3.85)

16. Wang K, Yang T, Wu Q, Zhao X, Nice EC, Huang C. Chemistry-based functional proteomics for drug target deconvolution.Expert Rev Proteomics. 2012;9(3):293-310. (IF: 3.85)

17. Jin P*, Wang K*, Huang C, Nice EC. Mining the fecal proteome: from biomarkers to personalised medicine.Expert Rev Proteomics. 2017;14(5):445-459. (IF: 3.85; co-first author)

18. Zhou L*, Wang K*, Li Q, Nice EC, Zhang H, Huang C. Clinical proteomics-driven precision medicine for targeted cancer therapy: current overview and future perspectives.Expert Rev Proteomics. 2016;13(4):367-81. (IF: 3.85; co-first author)

19. Jiang J*, Wang K*, Nice EC, Zhang T, Huang C. High-throughput screening of cellular redox sensors using modern redox proteomics approaches.Expert Rev Proteomics. 2015;12(5):543-55. (IF: 3.85; co-first author)

20. Wang K, Huang C, Nice E. Recent advances in proteomics: towards the human proteome.Biomed Chromatogr. 2014;28(6):848-57. (IF: 1.75)