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Distinguished Research Fellow Shuyu ZHANG

Distinguished Research Fellow Shuyu ZHANG ismainly engaged in the mechanism and prevention strategy of radioactive skin injury. In recent years, he has presided over four projects of the National Natural Science Foundation of China and five projects at the provincial and ministerial level. In 2015, he obtained the National Science Fund for Excellent Young Scholars, and in 2019 obtained the China National Nuclear Corporation (formerly Ministry of Nuclear Industry) Elite Talent Project. He led the team to use multi-dimensional "omics" to systematically explore the molecular spectroscopy changes in the progress of radiation skin injury and radiation lung injury, and revealed the mechanism of oxidative stress switch, free radical cascade effect, proteasome pathway, zinc ion steady state in regulating the progress of acute radiation injury and late fibrosis, provided new ideas and strategies for the prevention and treatment of radiation injury. He has published more than 60 SCI papers, and more than 40 first author and / or corresponding author papers, published in J Invest Dermatol, Int J Radiat Oncol * Biol * Phys, Oncogene, Free Radical Biol & Med, Carcinogenesis, Radiat Res and Radiat Oncol respectively;And some has been cited in high-impact journals such as Nat Genet, PNAS, Genome Res, Antioxid Redox Signal, J Invest Dermatol, Oncogene and Nucleic Acid Res. Part of his research has attracted the attention of international peers and was reported as a highlight paper by the Canadian Global Medical Discovery website. He served as the editorial board member of SCI source journal Exp Ther Med, Chinese Journal of Radiological Medicine and Protection, International Journal of Radiation Medicine and Nuclear Medicine; and He was invited as a reviewer by more than 20 magazines including Theranostics, Carcinogenesis, BBA (Basic Mechanism of Disease), Apoptosis, Int J Biol Sci,and Dose Response. He has obtained 8 national invention patents (4 first inventors) and the second prize of technological invention by the Ministry of Education and the second prize of technological invention by China Nuclear Energy Association (provincial and ministerial level).

Representative papers: (* Corresponding author)

1. Qiu Y, Gao Y, Yu D, Zhong L, Cai W, Ji J, Geng F, Tang G, Zhang H, Cao J, Zhang J*,Zhang S*. Genome-wide analysis reveals zinc transporter ZIP9 regulated by DNA methylation promotes radiation-induced skin fibrosis via the TGF-β signaling pathway.J Invest Dermatol. 2020;140:94-102.

2. Xiao Y, Mo W, Jia H, Yu D, Qiu Y, Jiao Y, Zhu W, Koide H, Cao J*,Zhang S*. Ionizing radiation induces cutaneous lipid remolding and skin adipocytes confer protection against radiation-induced skin injury.J Dermatol Sci. 2020;97(2):152-160.

3. Cao J, Zhu W, Yu D, Pan L, Zhong L, Xiao Y, Gao Y, Jiao Y, Zhang Q, Ji J, Yang H,Zhang S*, Cao J*. The Involvement of SDF-1α/CXCR4 Axis in Radiation-Induced Acute Injury and Fibrosis of Skin.Radiat Res. 2019;192(4):410-421.

4.Gu C, Luo J, Lu X, Tang Y, Ma Y, Yun Y, Cao J, Cao J, Huang Z, Zhou X*,Zhang S*. REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.Cancer Sci. 2019;110(3):962-972.

5.Xue J, Zhu W, Song J, Jiao Y, Luo J, Yu C, Zhou J, Wu J, Chen M, Ding WQ, Cao J*,Zhang S*. Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway.Oncogene. 2018;37(7):953-962.

6. Xue J, Yu C, Sheng W, Zhu W, Luo J, Zhang Q, Yang H, Cao H, Wang W, Zhou J, Wu J, Cao P, Chen M, Ding WQ, Cao J*,Zhang S*. The Nrf2/GCH1/BH4 axis ameliorates radiation-induced skin injury by modulating the ROS cascade.J Invest Dermatol. 2017;137(10):2059–2068.

7. Song J, Zhang H, Wang Z, Xu W, Zhong L, Cao J, Yang J, Tian Y, Yu D, Ji J*, Cao J,Zhang S*. The Role of FABP5 in Radiation-Induced Human Skin Fibrosis.Radiat Res. 2018;189(2):177-186.

8. Nie J, Zhang J, Wang L, Lu L, Yuan Q, An F,Zhang S*, Jiao Y*. Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4.J Exp Clin Cancer Res. 2017;36(1):183.

9. Wang W, Luo J, Sheng W, Xue J, Li M, Ji J, Liu P, Zhang X, Cao J,Zhang S*. Proteomic profiling of radiation-induced skin fibrosis in rats: targeting the ubiquitin-proteasome system.Int J Radiat Oncol*Biol*Phys.2016;95(2):751-60.

10. Tang Y, Cui Y, Li Z, Jiao Z, Zhang Y, He Y, Cheng G, Zhou Q, Wang W, Zhou X, Luo J*,Zhang S*. Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells.J Exp Clin Cancer Res. 2016;35(1):7.

11.Zhang S, Xue J, Zheng J, Wang S, Zhou J, Jiao Y, Geng Y, Wu J, Hannafon BN, Ding WQ*. The superoxide dismutase 1 (SOD1) 3'UTR maintains High expression of the SOD1 gene in cancer cells: The involvement of the RNA binding protein AUF1.Free Radic Biol Med.2015,85:33-44.

12.Zhang S*, Wang W, Gu Q, Xue J, Cao H, Tang Y, Xu X, Cao J*, Zhou J, Wu J, Ding WQ. Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 (PRDX-6) against ionizing radiation.Free Radical Biol & Med.2014;69:96-107.

13.Zhang S, Chen H, Zhao S, Cao J, Tong J, Lu J, Wu W, Shen H, Wei Q, Lu D*. REV3L 3’UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility.Oncogene.2013:10;32(2):242-50.

14.Zhang S*, Hao J, Xie F, Hu X, Liu C, Tong J, Zhou J, Wu J, Shao C*. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.Carcinogenesis. 2011;32(8):1183-9.

15.Zhang S, Lu J, Zhao X, Wu W, Wang H, Lu J, Wu Q, Chen X, Fan W, Wang F, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D*.A variant in theCHEK2promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.Carcinogenesis. 2010;31:2151-2158.