科研项目

1. 四川省科技厅应用基础研究项目，2022NSFSC0793，选择性α2A-AR别构调节剂的发现及其抗阿尔茨海默病活性研究，20万，2022年1月-2023年12月，主持；

2. 国家自然科学基金青年基金，81803648，新型α1A-AR亚型选择性别构调节剂的设计及作用机制研究，21万，2019年1月- 2021年12月，主持；

3. 四川大学创新火花项目，2018SCUH0039，新型α2A-AR选择性正向别构调节剂的设计及作用机制研究，24万，2018年8月- 2021年7月，主持；

4. 四川大学华西基础医学与法医学院青年教师科研基金，神经退行性疾病靶向小分子设计及机制研究，6万，2018年4月-2019年5月，主持；

5. 四川大学校青年教师科研启动基金，2016SCU11021，alpha1肾上腺素受体别构调节剂的研发，9万，2016年01月- 2017年12月，主持。

发表文章

1. Duan Z, Zhou W, He S, Wang W, Huang H, Yi L, Zhang R, Chen J*, Zan X, You C*, Gao X*. Intranasal Delivery of Curcumin Nanoparticles Improves Neuroinflammation and Neurological Deficits in Mice with Intracerebral Hemorrhage. Small Methods. 2024, 8(12): e2400304.

2. Liu J^#, Chen J^#, Zhang X, Wu Y, Qi X, Wang J, Gao X. Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment. CCL. 2024, 35(9):303-308.

3. Zhang X, Chen H, Wang C, Chen C, Liu L, Nie S, Gao X, Huang N*, Chen J*. Pan-cancer analysis of the role of α2C-adrenergic receptor (ADRA2C) in human tumors and validation in glioblastoma multiforme models. J Cancer. 2024, 15(17):5691-5709.

4. Wang B, Hu S, Teng Y, Chen J, Wang H, Xu Y, Wang K, Xu J, Cheng Y, Gao X. Current advance of nanotechnology in diagnosis and treatment for malignant tumors. Signal Transduct Target Ther. 2024, 9(1):200.

5. Zhuo W, Wang W, Zhou W, Duan Z, He S, Zhang X, Yi L, Zhang R, Guo A, Gou X, Chen J, Huang N, Sun X, Qian Z, Wang X, Gao X. A Targeted and Responsive Nanoprodrug Delivery System for Synergistic Glioma Chemotherapy. Small. 2024, 20(30): e2400630.

6. Chen J, Campbell AP, Wakelin LPG, Finch AM. Characterisation of bis(4-aminoquinoline)s as α1A adrenoceptor allosteric modulators. Eur J Pharmacol. 2022, 916:174659.

7. Li Z, Li J, Liu L, Deng W, Liu Q, Liu R, Zhang W, He Z, Fan L, Yang Y, Duan Y, Hou H, Wang X, Yang Z, Wang X, Chen S, Wang Y, Huang N*, Chen J*. Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor. Drug Des Devel Ther. 2020, 14: 2585-94.

8. You Y^#, Chen J^#, Zhu F, Xu Q, Han L, Gao X, Zhang X, Luo HR, Miao J, Sun X, Ren H, Du Y, Guo L, Wang X, Wang Y, Chen S, Huang N, Li J. Glutaredoxin 1 up-regulates deglutathionylation of α4 integrin and thereby restricts neutrophil mobilization from bone marrow. J Biol Chem. 2019, 294(8):2616-27.

9. Zhang F, Zhu F, Yang J, Zhang W, Liu K, Ren L, Xiong F, Lu K, Li D, Zeng R, Wang X, Li J, Chen S, Wang Y, Chen J*, Huang N*. High-mobility group protein N2 induces autophagy by activating AMPK/ULK1 pathway and thereby boosts UPEC proliferation within bladder epithelial cells. Biochem Biophys Res Commun. 2019, 513(1):193-200.

10. Hou H, Wang Y, Li Q, Li Z, Teng Y, Li J, Wang X, Chen J*, Huang N*. The role of RIP3 in cardiomyocyte necrosis induced by mitochondrial damage of myocardial ischemia-reperfusion. Acta Biochim Biophys Sin (Shanghai). 2018, 50(11):1131-40.

11. Yang X, Sha K, Xu G, Tian H, Wang X, Chen S, Wang Y, Li J, Chen J*, Huang N*. Subinhibitory Concentrations of Allicin Decrease Uropathogenic Escherichia coli (UPEC) Biofilm Formation, Adhesion Ability, and Swimming Motility. Int J Mol Sci. 2016, 17(7):979.

12. Chen J^#, Campbell AP^#, Urmi KF, Wakelin LP, Denny WA, Griffith R, Finch AM. Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines. Bioorg Med Chem. 2014, 22(21):5910-6.

13. Chen J, Murad AK, Wakelin LP, Denny WA, Griffith R, Finch AM. α₁-Adrenoceptor and serotonin 5-HT(1A) receptor affinity of homobivalent 4-aminoquinoline compounds: an investigation of the effect of linker length. Biochem Pharmacol. 2013, 85(10):1534-41.