近五年主持主要项目:
1.氯胺酮成瘾不同脑区特征代谢标志物及代谢通路的研究 (批准编号:82072111) ,国家自然科学基金面上项目,2021年-2024年,负责人,在研;
2.新型毒品致精神障碍的外周免疫调控机制研究及代谢组学鉴识体系建立(批准编号:82030057), 国家自然科学基金重点项目,2021年-2025年,合作单位负责人,在研;
3.典型新精神活性物质代谢组学及快速检测设备研究(批准编号:2023YFS0418)四川省重点研发项目,2023年-2024年,合作单位负责人,在研;
4.毒品查缉平台建设(批准编号:2019YFS0066),四川省重点研发项目,2019年-2020年,负责人,已结题;
5.基于代谢组学对氯胺酮引起的机体代谢特征及毒性机制研究(批准编号:81373239),国家自然科学基金面上项目,2014年-2017年,负责人,已结题。
近五年发表的论文(通讯作者):
1. Shiyong Fang,Xinhua Dai1,Xiaoling Shi,Li Xiao,Yi Ye1 • Linchuan Liao.A pilot study investigating early postmortem interval of rats based on ambient temperature and postmortem interval‑related metabolites in blood. Forensic Science, Medicine and Pathology. Published online: 02 June 2023, https://doi.org/10.1007/s12024-023-00643-0.
2. Wei Y, Xiao L, Fan W, Yang H, Fu Y, Ye Y, Wang X, Wen D, Cheng A, Liao L. Comprehensive metabolomic characterization of the hippocampus in a ketamine mouse model of schizophrenia. Biochem Biophys Res Commun. 2022 Sep 21;632:150-157.
3. Hongkun Yang, Lina Dai, Yue Wang, Jinlei Liu, Shi Qiu, Jie Gu, Huiru Bai, Amin Wurita, Linchuan Liao*. Analytical method for detection and quantification of new emerging drug etaqualone in human blood and urine by gas chromatography tandem mass spectrometry. Legal Medicine. 2022; 5(59): 102125.
4. Wei Y, Xiao L, Fan W, Zou J, Yang H, Liu B, Ye Y, Wen D, Liao L. Astrocyte Activation, but not Microglia, Is Associated with the Experimental Mouse Model of Schizophrenia Induced by Chronic Ketamine. J Mol Neurosci. 2022 Sep;72(9):1902-1915.
5. Wang X, Zhang C, Li Y, Xu T, Xiang J, Bai Y, Zhang Y, Wang Q, Zhang T, Liao L*. High-Throughput mRNA Sequencing Reveals Potential Therapeutic Targets of Febuxostat in Secondary Injury After Intracerebral Hemorrhage. Front Pharmacol. 2022 Jun 23;13:833805.
6. Wang, XY; Liu, YP……Liao, LC*. Evaluation of the effects of four types of tea on the activity of cytochrome P450 enzymes with a probe cocktail and HPLC-MS/MS. Ann Transl Med. 2022;10(9):504.
7. Xiang J, Xu N, Wang X, Li S, Yu Q, Liang M, Nan F, Shu S, Yan R, Zhu Y, Liao L*. Bioequivalence of 2 Aripiprazole Orally Disintegrating Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions. Clin Pharmacol Drug Dev. 2021 Aug;10(8):840-849.
8. Xiao L, Ye Y, Wang Y, Dai X, Fang S, Wei Y, Zheng Y, Wu H, Fu Y, Liao L*. A 9-year retrospective study of poisoning-related deaths in Southwest China (Sichuan). Forensic Sci Int. 2021 Jan;318:110558.
9. Xie R, Hong S, Ye Y, Wang X, Chen F, Yang L, Yan Y, Liao L*. Ketamine Affects the Expression of ErbB4 in the Hippocampus and Prefrontal Cortex of Rats. J Mol Neurosci. 2020 Jun;70(6):962-967.
10. Xie R, Xie J, Ye Y, Wang X, Chen F, Yang L, Yan Y, Liao L*. mTOR Expression in Hippocampus and Prefrontal Cortex Is Downregulated in a Rat Model of Schizophrenia Induced by Chronic Administration of Ketamine. J Mol Neurosci. 2020 Feb;70(2):269-275.