师资队伍

科研成果

教授、博导

联系方式:
1499463946@qq.com

研究项目:

1. 获得过四川省科技厅项目“人参皂甙对皮肤细胞抗衰老作用研究”,项目编号:02SY029-137。

2. 参加过国家自然科学基金课题“穿心莲内酯上调防御素表达作用研究”,批准号 30672650。

3. 作为主要研究者,参与973计划-国家重点基础研究计划,“基于以功效为核心的中药药性理论研究--功效研究:金银花等12味中药功效作用机理研究”,编号2007CB512604-1,本人作为该项目分课题负责人,指导该项目的完成。

4. 与多个药厂合作,帮助他们筛选新药和评价药物的有效性和安全性,同时,帮助其药厂准备新药临床前资料,使其申报新药临床试验。其课题包括:“盐酸头孢替安酯体内外药效学试验”;“埃克特注射液抗肺癌作用的药效学实验”;“复尔康注射液拆方制剂对白血病的抑制作用”等。这些项目的完成,为企业获得新药证书发挥了很好的作用,而且产生了很好的经济效益。

近期发表文章:

1. Yiying Wu, Yi Song, Yao Xiong, Xiaodong Wang, Ke Xu, Bin HanYang Bai, Li Li, Yuanyuan Zhang, Liming Zhou. MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer,Cell Physiol Biochem 2017;43:945-958

2. Yuanqi Liu, Wei Ren, Yang Bai, Lihong Wan, Xiaodong Sun, Yin Liu, Wenbi Xiong, YuanYuan Zhang, Liming Zhou. Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis, Journal of Natural Medicines, 2018, 72:481-492

3. Bin Han, Yuan-Yuan Zhang, Ke Xu, Yang Bai, Li-Hong Wan, Shi-Kun Miao, Ke-Xian Zhang, Hong-Wei Zhang, Yin Liu, Li-Ming Zhou. NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer, Am J Cancer Res 2018;8(5):810-823

4. Rong Li, Xiuying Ma, Yingqi Song, Yuanyuan Zhang, Wen bi Xiong, Li Li, Liming Zhou. Anti-colorectal cancer targets of resveratrol and biological molecular mechanism: Analyses of network pharmacology, human and experimental data, J Cell Biochem. 2019; 120(7): 11265-11273.

5. Ke Xu, Bin Han, Yang Bai, Xiu-Ying Ma, Zhen-Ni Ji, Yao Xiong, Shi-Kun Miao, Yuan-Yuan Zhang and Li-Ming Zhou. MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer, Cell Death and Disease, 2019, 15;10(3):152-166

6 . Li R, Song Y, Ji Z, Li L, Zhou L. Pharmacological biotargets and the molecular mechanisms of oxyresveratrol treating colorectal cancer: Network and experimental analyses. Biofactors. 2020 ;46(1):158-167.

7. Yang. Bai, H Wu, Bin, Han, Ke Xu, Yuanqi Liu, Yin Liu, Shikun Miao, Yuanyuan Zhang and Liming Zhou. Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer, 2020 ONCOLOGY LETTERS: 124(20), 1-6.

8. Huixu Xie, Lisa Yang, Qin Hu, Yingqi Song, Xiaoyi Wang, Liming Zhou, Longjiang Li, Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein1 in tongue cell carcinoma, Head & Neck. 2020;1–15.

9. Rong Li, Lin Cheng, Qi Wang and Liming Zhou. Comparative Transcriptomic Analysis Reveals the Immunosuppressive Targets of Mesalazine in Dextran Sulfate Sodium-Induced Ulcerative Colitis, Frontiers in Genetics. 2021 Aug 11;12: 698983. doi: 10.3389/fgene.2021.698983. eCollection 2021

10. He Li, Linling Liu, Hong-ying Chen, Xin Yan, Ru-li Li, Jie Lan, Kun-yue Xue, Xue Li, Cai-li Zhuo, Lan Lin, Ling-yu Li, Zhuang Wu, Die Zhang, Xue-mei Wang, Wen-jing Huang, Yingling Wang, Wei Jiang, Liming Zhou. Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis. Toxicology and Applied Pharmacology, Volume 444, 1 June 2022, 116037

11. Hui Liu, Wenqi Lei, Zhigui Li, Xiaodong Wang, Liming Zhou. NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK. J Cell Mol Med. 2023; 27(8):1069-1082. doi: 10.1111/jcmm.17706.

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