教学成果-四川大学华西基础医学与法医学院

教学成果

副教授、硕导

病理生理学教研室

联系方式：

jingyuli@scu.edu.cn

承担本科生、留学生和研究生多层次课程，包括病理生理学、机能实验学、基础医学英语、基础医学研究前沿与挑战、医学汉语、发病机制等。参编国家级规划教材《机能实验学》《病理生理学》等4本，主持教改项目1项，发表教改论文1篇。曾获四川大学”“‘探究式-小班化’教学质量优秀奖”等教学奖励。

教学成果
科研成果
其他

暂无

部分主持项目：

1.谷氧还蛋白1通过调控巨噬细胞极化介导直肠癌的发生发展，四川省自然科学基金，2022.01-2023.12，20万元

2.宣肺败毒方对中性粒细胞的调节效应研究，组分中药国家重点实验室开放课题，2022.01-2023.06，8万元

3.Grx1介导的整合素S-谷胱甘肽化调节巨噬细胞的粘附及抗菌功能，四川省科协青年人才托举工程项目，2019.01-2020.12，10万元

4.S-谷胱甘肽化对炎症细胞因子活性调节的研究，四川大学优秀青年学者基金，2016.01-2018.12，20万元

5.Grx1介导的α4β1谷胱甘肽化调节骨髓中性粒细胞的释放，国家自然科学基金青年科学基金，2015.01-2017.12，25万元

文章

1. Zaibing Li#, Jingyu Li#, Liyan Liu, Wenyi Deng, Qingrong Liu, Ruofan Liu, Wen Zhang, Zaiqing He, Lei Fan, Yingzhuo Yang, Yun Duan, Huifang Hou, Xinyuan Wang, Zhimei Yang, Xiaoying Wang, Shanze Chen, Yi Wang, Ning Huang*, Junli Chen*. Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor; Drug Design, Development and Therapy, 2020,14:2585-2594.

2.Lijuan Guo#, Shanze Chen#, Qingrong Liu, Hongyu Ren, Yuhao Li, Junyue Pan, Yuhan Luo, Tongzhou Cai, Ruofan Liu, Junli Chen, Yi Wang, Xiaoying Wang, Ning Huang*, Jingyu Li*; Glutaredoxin 1 regulates macrophage polarization through mediating glutathionylation of STAT1. Thoracic Cancer, 2020,11(10):2966-2974.

3. Yuanyuan You#, Junli Chen#, Feimei Zhu, Qian Xu, Lu Han, Xiang Gao, Xiaoyu Zhang, Hongbo R. Luo, Junming Miao, Xiaodong Sun, Hongyu Ren, Yu Du, Lijuan Guo, Xiaoying Wang, Yi Wang, Shanze Chen, Ning Huang*,Jingyu Li*; Glutaredoxin 1 up-regulates deglutathionylation of α4 integrin and thereby restricts neutrophil mobilization from bone marrow; Journal of Biological Chemistry, 2019, 294(8): 2616-2627.

4. Jia-Chuan Li, Xiao-fei Shen, Jun-Ao Shao, Meng-Min Tao, Jian Gu, Jingyu Li*, Ning Huang*; The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats; Drug Design, Development and Therapy, 2018, 12: 2695-2706.

5. Heng Li, Xiao-fei Shen, Xin-e Zhou, Yan-e Shi, Lu-xia Deng, Yi Ma, Xiao-ying Wang, Jing-yu Li*, Ning Huang*; The antibacterial mechanism of high-mobility group nucleosomal binding domain 2 (HMGN2) on the gram-negative bacteria Escherichia coli; Journal of Zhejiang University-Science B, 2017, 18(5):410-420.

6. Xiao-Fei Shen#, Yan Teng#, Kai-Hui Sha, Xin-Yuan Wang, Xiao-Long Yang, Lai-Bin Ren, Xiao-Ying Wang, Jingyu Li*, Ning Huang*; Dietary flavonoid luteolin attenuates uropathogenic Escherichia. Coli invasion of the urinary bladder; Biofactors, 2016, 42(6): 674-685.

7. Xiao-fei Shen, Lai-bin Ren, Yan Teng, Shuang Zheng, Xiao-long Yang, Xiao-juan Guo, Xin-yuan Wang, Kai-hui Sha, Na Li, Guang-ya Xu, Han-wen Tian, Xiao-ying Wang, Xiao-kang Liu, Jingyu Li*, Ning Huang*; Luteolin decreases the attachment, invasion and cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation; Food and Chemical Toxicology, 2014, 72: 204-211.

8. Fan Zhao#, Jingyu Li#, Ning Zhou, Jiro Sakai, Yuan Gao, Junfeng Shi, Bronia Goldman, Hayley M. Browdy, Hongbo R. Luo, and Bing Xu; De novo chemoattractants form supramolecular hydrogels for immunomodulating neutrophils in vivo; Bioconjugate Chemistry, 2014, 25(12):2116-2122.

9. Jiro Sakai#, Jingyu Li#, Kulandayan K. Subramanian#, Subhanjan Mondal, Besnik Bajrami, Hidenori Hattori, Yonghui Jia, Bryan C. Dickinson, Jia Zhong, Keqiang Ye, Christopher J. Chang, Ye-Shih Ho, Jun Zhou, Hongbo R. Luo; Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils; Immunity, 2012, 37(6): 1037-1049.

专利

.Fan Zhao, Jingyu Li, Hongbo R. Luo, Bing Xu; Supramolecular hydrogel of fMLF-based molecules and use thereof; US patent: US 10,232,037 B2;2019-03-19.

学术任职：中国病理生理学会会员

中国细胞生物学学会会员

四川省生理科学会青年委员会委员

中文核心期刊《癌症》编委

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TEACHERS

师资队伍

师资队伍

教学成果

副教授、硕导

联系方式：

jingyuli@scu.edu.cn