研究方向：
1. 心脑血管疾病发病机制及介入治疗
2. 力学-生物学信号耦合及转导机制
3. 心血管疾病的纳米药物递送治疗策略
4. 微流控器官芯片体外疾病模型的开发
科研项目：
1. 国家自然科学基金面上项目，“构建三维微流控血管芯片探索颅内动脉瘤血管重塑机制”（32371370）
2. 国家自然科学基金面上项目，“流体剪切力诱导内皮/间质转化（EndMT）参与调控脑缺血再灌注中炎症应答的力学生物学机制探索”（32071312）
3. 国家自然科学基金面上项目，“力学敏感YAP通路介导流体剪切力调控血脑屏障的力学生物学机制探索”（31870939）
4. 国家自然科学基金面上项目，“血管支架再内皮化细胞来源及其协同作用参与支架段血管修复的力学生物学机制研究”（31570948）
5. 国家自然科学基金青年基金项目，“材料表面化学调控血管内皮细胞粘附和迁移的生物力学机制”（31300775）
代表论文：
1. Fei Fang, Tang Feng, Jianwei Li, Huaiyi Zhang, Qin Wang, Yidan Chen, Guixue Wang,Yang Shen*, Xiaoheng Liu*. Cathepsin K Contributed to Disturbed Flow-induced Atherosclerosis is Dependent on Integrin-actin Cytoskeleton-NF-κB Pathway,Genes Dis, 2023, 10, 583-595
2. Xiaoli Wang,Yang Shen,Min Shang,Xiaoheng Liu,Lance L Munn.Cardiovasc Res.2023, 119(8):1656-1675.
3. ZhenyeWang, Jia Ma,HongyanYue,ZheweiZhang, FeiFang,Guixue Wang, XiaohengLiu,Yang Shen*. VascularSmoothMuscleCells inIntracranialAneurysms.Microvasc Res, 2023,149: 104554
4. Fei Fang, Yinghao Ni, Hongchi Yu, Hongmei Yin, Fan Yang, Chunli Li, Denglian Sun, Tong Pei, Jia Ma, Li Deng, Huaiyi Zhang, Guixue Wang, Song Li*,Yang Shen* and Xiaoheng Liua*, Inflammatory Endothelium-targeted and Cathepsin Responsive Nanoparticles are Effective Against Atherosclerosis,Theranostics, 2022,12(9): 4200-4220
5. Hongchi Yu, Jia He, Guanyue Su, Yuelong Wang, Fei Fang, Wenxing Yang, Kaiyun Gu, Nai Yang Fu, Yunbing Wang*,Yang Shen*, Xiaoheng Liu*. Fluid Shear Stress Activates YAP to Promote Epithelial-mesenchymal Transition in Hepatocellular Carcinoma,Mol Oncol, 2021, 15(11):3164-3183.
6. Xiaoli Wang, Fei Fang, Yinghao Ni, Hongchi Yu, Jia Ma, Li Deng, Chunli Li,Yang Shen* and Xiaoheng Liu*. The Combined Contribution of Vascular Endothelial Cell Migration and Adhesion to Stent Re-endothelialization.Front Cell Dev Biol, 2021, 9:641382.
7. Yang Shen, Bin Cao, Noah R. Snyder, Kevin M. Woeppel, James R. Eles, Xinyan Tracy Cui. ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood-brain barrier.J Nanobiotechnol. 2018, 16(1):13.
8. Yang Shen, Min Gao, Yunlong Ma, Hongchi Yu, Fu-zhai Cui, Hans Gregersen,Qingsong Yu, Guixue Wang, Xiaoheng Liu*.Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration.Colloid Surf B Biointerfaces,2015, 126:188-197.
9. Yang Shen,Yunlong Ma, Min Gao, Yi Lai, Guixue Wang, Qingsong Yu, Fu-zhai Cui, Xiaoheng Liu.Integrins-FAK-Rho GTPases Pathway in Endothelial Cells Sense and Response to Surface Wettability of Plasma Nanocoatings.ACS Appl Mater Inter, 2013, 5(11):5112-5121.
10. Yang Shen, Guixue Wang, Liang Chen, Hao Li, PingYu, Mengjun Bai, Qin Zhang, James Lee, Qingsong Yu. Investigation of surface endothelialization on biomedical nitinol (NiTi) alloy: Effects of surface micro-patterning combined with plasma nanocoating.Acta Biomater, 2009, 5(9):3593-3604.
