研究方向：肿瘤耐药机制与靶向治疗；肿瘤免疫耐受和免疫治疗。指导博士研究生和硕士研究生多名，指导本科生毕业论文设计及大学生创新训练计划项目多项。研究成果以通讯作者或第一作者（含共同）发表在Cancer Discovery, Clinic Cancer Research, J Invest Dermatol和apoptosis等国际期刊上，在Nature Genetic（第三作者，2007），Nature Cell Biology(第四作者，2018)和Nature Communication(第四作者，2019年)发表合作研究成果，总影响因子超过184，被他引超过900次。
1. Yari H, Jin L, Teng L, Wang Y, Wu Y, Liu GZ, Gao W, Liang J, Xi Y, Feng YC, Zhang C, Zhang YY, Tabatabaee H, La T, Yang RH, Wang FH, Yan XG, Farrelly M, Scott R, Liu T, Thorne RF, Guo ST, Zhang XD. LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription. Nat Commun. 2019 Nov 25;10(1):5334. doi: 10.1038/s41467-019-13313-z.
2. G, Zhang X, Liu Z, Zhu S, Shen P, Zhang H, Zhang M, Chen N, Zhao J, Chen J, Liu J, Dai J, Wang Z, Zhu X, Wang Y, Zeng H. The Adiponectin-AdipoR1 Axis Mediates Tumor Progression and Tyrosine Kinase Inhibitor Resistance in Metastatic Renal Cell Carcinoma. Neoplasia. 2019 Sep;21(9):921-931. doi:10.1016/j.neo.2019.07.004. Epub 2019 Aug 8. PubMed PMID: 31401413; PubMed Central PMCID: PMC6700451.
3. Ma Q, Gu L, Liao S, Zheng Y, Zhang S, Cao Y, Zhang J, Wang Y. NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo. Apoptosis. 2019 Feb;24(1-2):83-94. doi: 10.1007/s10495-018-1498-z. PubMed PMID: 30515612.
4. Yang Y, Wang T, Chen D, Ma Q, Zheng Y, Liao S, Wang Y, Zhang J. Quercetin preferentially induces apoptosis in KRAS-mutant colorectal cancer cells via JNK signaling pathways. Cell Biol Int. 2019 Feb;43(2):117-124. doi:10.1002/cbin.11055. PubMed PMID: 30203888.
5. Ma QZ, Yang YW, Ma YL, Liao SP, Zheng YJ, Zhang S, Cao YY, Zhang J, Wang YF.[Correlation of K-ras Gene Mutations with the Protein Expressions of TAK1 and MAP4K2 in Colorectal Cancer]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Jan;50(1):61-65. Chinese. PubMed PMID: 31037906.
6. Hu WL, Jin L, Xu A, Wang YF, Thorne RF, Zhang XD, Wu M. GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability. Nat Cell Biol. 2018 Apr;20(4):492-502. doi: 10.1038/s41556-018-0066-7. Epub 2018 Mar 28. PubMed PMID: 29593331.
7. Ma Q, Mao Z, Du J, Liao S, Zheng Y, Zhi M, Zhang J, Wang Y. Association between an insertion/deletion polymorphism in the interleukin-1α gene and the risk of colorectal cancer in a Chinese population. Int J Biol Markers. 2018 Jul 1:1724600818785069. doi: 10.1177/1724600818785069. [Epub ahead of print] PubMed PMID: 30016900.
8. Zhao Y, Mao Z, Pang H, Zhao X, Zhang S, Gao Z, Yang Y, Fang T, Ma Q, Ma X, Wang Y, Zhang J. [Association of programmed cell death 1 (PDCD1) gene polymorphisms with colorectal cancer among Han Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018 Apr 10;35(2):219-223. doi: 10.3760/cma.j.issn.1003-9406.2018.02.016. Chinese. PubMed PMID: 29652996.
9. Wang YF, Liu F, Sherwin S, Farrelly M, Yan XG, Croft A, Liu T, Jin L, Zhang XD, Jiang CC. Cooperativity of HOXA5 and STAT3 Is Critical for HDAC8 Inhibition-Mediated Transcriptional Activation of PD-L1 in Human Melanoma Cells. J Invest Dermatol. 2018 Apr;138(4):922-932. doi: 10.1016/j.jid.2017.11.009. Epub 2017 Nov 22. PubMed PMID: 29174371.
10. Du J, Wang Y, Chen D, Ji G, Ma Q, Liao S, Zheng Y, Zhang J, Hou Y. BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB. Cancer Lett. 2016 Dec 28;383(2):145-153. doi: 10.1016/j.canlet.2016.10.002. Epub 2016 Oct 6. PubMed PMID: 27721019.
11. Wang Y, Lv J, Cheng Y, Du J, Chen D, Li C, Zhang J. Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent. PLoS One. 2015 Apr 10;10(4):e0124812. doi: 10.1371/journal.pone.0124812. eCollection 2015. PubMed PMID: 25860257; PubMed Central PMCID: PMC4393283.
12. Wang X, Zhang J, Cheng Y, DU J, Chen D, Yang Z, Wang Y, Huang N. [Human caspase-14 expression in malignant melanoma and its significance]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Nov;30(11):1180-3. Chinese. PubMed PMID: 25374083.
