科研领域:器官修复中的血管微环境
主要成果:
(1) 丁楅森、曹中炜、张岩、张华,血管微环境对器官再生和纤维化的调控,四川省自然科学奖一等奖(2024年度)。 (第一完成人)
(2) Yang N, Li XX, Huang WW, Ji GL, Luo W, Jiang FM, Zeng H, Chen YL, Chen Y, Qiao LN, Chen L, Rafii S, Wang W, Zheng A,Ding BS, Cao ZW.MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy. Nature Cell Biology,2025,27(9):1526-1542.(共同通讯作者)
(3) Mo CH, Li H, Yan ML, Xu SY, Wu JY, Li JC, Yang XC, Li YY, Yang J, Su XP, Liu J, Wu C, Wang Y, Dong HH, Chen L, Dai LZ, Zhang M, Pu Q, Yang LM, Ye TH, Cao ZW,Ding BS.Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis.Cell Metabolism,2024,36(8):1839-1857.e12.(最后通讯作者)
(4) Ma J, Zhang LY, Zhang X, Zhang LL, Zhang H, Zhu YL, Huang XM, Zhang T, Tang XD, Wang Y, Chen L, Pu Q, Yang LM, Cao ZW,Ding BS.Inhibiting endothelialRhojblocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration.Science Translational Medicine,2024,16(762):eado5266.(最后通讯作者)
(5) Zhang H, Ma YY, Cheng XY, Wu DB, Huang XM, Chen B, Ren YF, Jiang W, Tang XQ, Bai T, Chen YT, Zhao YL, Zhang CX, Xiao X, Liu J, Deng Y, Ye TH, Chen L, Liu HM, Friedman SL, Chen LP,Ding BS, Cao ZW. Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis.Science Translational Medicine, 2021, 13(614): eabd1206.(共同通讯作者)
(6) Chen YT, Pu Q, Ma YY, Zhang H, Ye TH, Zhao CJ, Huang XJ, Ren YF, Qiao LN, Liu HM, Esmon CT,Ding BS, Cao ZW. Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis.Cell Metabolism, 2021, 33(2): 395-410 e4.(责任作者)
(7) Ding BS, Yang DW, Swendeman SL, Christoffersen C, Nielsen LB, Friedman SL, Powell CA, Hla T, Cao ZW. Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.Developmental Cell, 2020, 53(6): 677-690 e4.(一作兼共同通讯)
(8) Cao ZW, Ye TH, Sun Y, Ji GL, Shido K, Chen YT, Luo L, Na F. Li XY, Huang Z, Ko JL, Mittal V, Qiao LN, Chen C, Martinez FJ, Rafii S,Ding BS. Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis.Science Translational Medicine, 2017, 9(405): eaai8710.(最后通讯作者)
(9) Cao ZW, Scandura JM, Inghirami GG, Shido K,Ding BS, Rafii S. Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells.Cancer Cell, 2017, 31(1): 110-126.(共同通讯作者)
(10) Rafii S, Butler JM,Ding BS.Angiocrine functions of organ-specific endothelial cells.Nature,2016,529(7586):316-225.(最后通讯作者)
(11) Cao ZW, Lis R, Ginsberg M, Chavez D, Shido K, Rabbany SY, Fong GH, Sakmar TP, Rafii S,Ding BS. Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis.Nature Medicine, 2016, 22(2): 154-162.(最后通讯作者)
(12) Rafii S, Cao ZW, Lis R, Siempos, II, Chavez D, Shido K, Rabbany SY,Ding BS. Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration.Nature Cell Biology, 2015, 17(2): 123-136.(唯一通讯作者)
(13) Ding BS, Cao ZW, Lis R, Nolan DJ, Guo PP, Simons M, Penfold ME, Shido K, Rabbany SY, Rafii S. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.Nature, 2014, 505(7481): 97-102.(一作兼共同通讯)
(14) Ding BS, Nolan DJ, Guo PP, Babazadeh AO, Cao ZW, Rosenwaks Z, Crystal RG, Simons M, Sato TN, Worgall S, Shido K, Rabbany SY, Rafii S. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization.Cell, 2011, 147(3): 539-553.(第一作者)
(15) Ding BS, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, Sato TN, Rabbany SY, Rafii S.Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration.Nature, 2010,468(7321):310-315.(第一作者)