【研究方向】

1.   肿瘤氧化还原信号调控与代谢

2. 抗肿瘤药物靶点的鉴定和作用机制

【代表性论文】

1. Wu X, Luo L, Wang M, Dong L, Fan J, Zeng Y, Li S, Wang K. PRDX6 prevents NNMT ubiquitination and degradation as a nonenzymatic mechanism to promote ovarian cancer progression. Adv Sci. 2025. doi: 10.1002/advs.202416484

2. Li S, Dong L, Wang K. Current and future perspectives of lysine lactylation in cancer. Trends Cell Biol. 2025; doi: 10.1016/j.tcb.2024.12.015.

3. Chen Z, Fan J, Chen X, Yang K, Wang K. Oxidative stress and redox signaling in gastric cancer: from mechanisms to therapeutic implications. Antioxidants. 2025; doi: 10.3390/antiox14030258.

4. Luo L, Wu X, Fan J, Dong L, Wang M, Zeng Y, Li S, Yang W, Jiang J, Wang K. FBXO7 Ubiquitinates PRMT1 to Suppress Serine Synthesis and Tumor Growth in Hepatocellular Carcinoma. Nat Commun. 2024;15(1):4790.

5. Mu B, Zeng Y, Luo L, Wang K. Oxidative Stress-mediated Protein Sulfenylation in Human Diseases: Past, Present, and Future. Redox Biol. 2024;76:103332.

6. Dong L, Luo L, Wang Z, Lian S, Wang M, Wu X, Fan J, Zeng Y, Li S, Lv S, Yang Y, Chen R, Shen E, Yang W, Li C, Wang K. Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma. Free Radic Biol Med. 2024; 220:111-24.

7. Wang K, Luo L, Fu S, Wang M, Wang Z, Dong L, Wu X, Dai L, Peng Y, Shen G, Chen HN, Nice EC, Wei X, Huang C. PHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and Represents a Therapeutic Vulnerability in Hepatocellular Carcinoma. Nat Commun. 2023;14(1):1011.

8. Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B. Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy. Autophagy. 2023;19(12):3132-50 (一作和共同通讯)

9. Dong L, He J, Luo L, Wang K. Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals. Pharmaceuticals. 2023;16(1):92. (ESI高被引论文)

10. Jiang J, Peng L, Wang K, Huang C. Moonlighting Metabolic Enzymes in Cancer: New Perspectives on the Redox Code. Antioxid Redox Signal. 2021; 34(13):979-1003 (共同通讯) .

11. Jiang J, Zhang L, Chen H, Lei Y, Zhang T, Wang Y, Jin P, Lan J, Zhou L, Huang Z, Li B, Liu Y, Gao W, Xie K, Zhou L, Nice EC, Peng Y, Cao Y, Wei Y, Wang K, Huang C. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. Autophagy. 2020;16(1):106-22 (共同通讯).

12. Huang Z, Zhou JK, Wang K, Chen H, Qin S, Liu J, Luo M, Chen Y, Jiang J, Zhou L, Zhu L, He J, Li J, Pu W, Gong Y, Li J, Ye Q, Dong D, Hu H, Zhou Z, Dai L, Wei Y, Huang C, Wei X, Peng Y. PDLIM1 inhibits tumor metastasis through activating Hippo signaling in hepatocellular carcinoma. Hepatology. 2020;71(5):1643-59 (共同一作).

13. Wang K, Jiang J, Lei Y, Zhou S, Wei Y, Huang C. Targeting Metabolic-Redox Circuits for Cancer Therapy. Trends Biochem Sci. 2019;44(5):401-14 (ESI高被引论文) .

14. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Nice EC, Wu M, Huang C, Wei Y. Identification of ANXA2 (annexin A2) as a Specific Bleomycin Target to Induce Pulmonary Fibrosis by Impeding TFEB-mediated Autophagic Flux. Autophagy. 2018;14(2):269-82.

15.Jiang J, Wang K, Chen Y, Chen H, Nice EC, Huang C. Redox regulation in tumor cell epithelial-mesenchymal transition: Molecular basis and therapeutic strategy. Signal Transduct Target Ther. 2017;2:e17036 (共同一作) .