2015年于四川大学生物治疗全国重点实验室毕业，获理学博士学位，随后在四川大学生物治疗全国重点实验室从事博士后研究；现任四川大学华西基础医学与法医学院研究员。2013年作为访问学者赴澳大利亚Monash University学习交流1年。

共发表论文60余篇。其中，以第一作者或通讯作者（含共同）在Nat Commun（2篇）、Adv Sci、Autophagy（5篇）、Hepatology、Cancer Res、Trends Cell Biol、Trends Biochem Sci、STTT、Redox Biol、Med Res Rev等期刊发表论文38篇，其中16篇IF＞10分。被Cell、Nat Rev Drug Discov等期刊引用4000余次，其中3篇被引超过250次，单篇最高被引423次，H-index为35。任Cancer Metab副主编，Expert Rev Proteomics、Malignancy Spectrum 编委，Antioxidants、Life客座编辑；Lancet Reg Health-Eu、STTT、Adv Sci、Cell Chem Biol、Oncogene、BBA-Rev Cancer等期刊审稿人。

主持国家自然科学基金面上项目（4项）、四川省杰青等项目；获教育部自然科学奖一等奖、四川大学学术新人奖、四川大学青年科技人才奖、四川大学好未来优秀学者奖、四川大学优秀科研人才奖；入选四川大学双百人才工程B计划、四川省学术和技术带头人后备人选、四川省卫生健康委员会学术技术带头人后备人选、四川大学青年科技学术带头人培育项目。

讲授《科研素养与创新能力培养》、《开放式医学创新论坛》等课程；指导大创项目10余项，其中3项获国家级立项，1 项获省级立项，1项结题优秀；大创成果在国际学术刊物发表论文4篇（本科生均为论文一作）；连续被评为四川大学大学生创新创业与实践教育优秀指导教师（2019、2020）。

【研究方向】

1.   肿瘤氧化还原信号调控与代谢

2. 抗肿瘤药物靶点的鉴定和作用机制

【代表性论文】

1. Wu X, Luo L, Wang M, Dong L, Fan J, Zeng Y, Li S, Wang K. PRDX6 prevents NNMT ubiquitination and degradation as a nonenzymatic mechanism to promote ovarian cancer progression. Adv Sci. 2025. doi: 10.1002/advs.202416484

2. Li S, Dong L, Wang K. Current and future perspectives of lysine lactylation in cancer. Trends Cell Biol. 2025; doi: 10.1016/j.tcb.2024.12.015.

3. Chen Z, Fan J, Chen X, Yang K, Wang K. Oxidative stress and redox signaling in gastric cancer: from mechanisms to therapeutic implications. Antioxidants. 2025; doi: 10.3390/antiox14030258.

4. Luo L, Wu X, Fan J, Dong L, Wang M, Zeng Y, Li S, Yang W, Jiang J, Wang K. FBXO7 Ubiquitinates PRMT1 to Suppress Serine Synthesis and Tumor Growth in Hepatocellular Carcinoma. Nat Commun. 2024;15(1):4790.

5. Mu B, Zeng Y, Luo L, Wang K. Oxidative Stress-mediated Protein Sulfenylation in Human Diseases: Past, Present, and Future. Redox Biol. 2024;76:103332.

6. Dong L, Luo L, Wang Z, Lian S, Wang M, Wu X, Fan J, Zeng Y, Li S, Lv S, Yang Y, Chen R, Shen E, Yang W, Li C, Wang K. Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma. Free Radic Biol Med. 2024; 220:111-24.

7. Wang K, Luo L, Fu S, Wang M, Wang Z, Dong L, Wu X, Dai L, Peng Y, Shen G, Chen HN, Nice EC, Wei X, Huang C. PHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and Represents a Therapeutic Vulnerability in Hepatocellular Carcinoma. Nat Commun. 2023;14(1):1011.

8. Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B. Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy. Autophagy. 2023;19(12):3132-50 (一作和共同通讯)

9. Dong L, He J, Luo L, Wang K. Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals. Pharmaceuticals. 2023;16(1):92. (ESI高被引论文)

10. Jiang J, Peng L, Wang K, Huang C. Moonlighting Metabolic Enzymes in Cancer: New Perspectives on the Redox Code. Antioxid Redox Signal. 2021; 34(13):979-1003 (共同通讯) .

11. Jiang J, Zhang L, Chen H, Lei Y, Zhang T, Wang Y, Jin P, Lan J, Zhou L, Huang Z, Li B, Liu Y, Gao W, Xie K, Zhou L, Nice EC, Peng Y, Cao Y, Wei Y, Wang K, Huang C. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. Autophagy. 2020;16(1):106-22 (共同通讯).

12. Huang Z, Zhou JK, Wang K, Chen H, Qin S, Liu J, Luo M, Chen Y, Jiang J, Zhou L, Zhu L, He J, Li J, Pu W, Gong Y, Li J, Ye Q, Dong D, Hu H, Zhou Z, Dai L, Wei Y, Huang C, Wei X, Peng Y. PDLIM1 inhibits tumor metastasis through activating Hippo signaling in hepatocellular carcinoma. Hepatology. 2020;71(5):1643-59 (共同一作).

13. Wang K, Jiang J, Lei Y, Zhou S, Wei Y, Huang C. Targeting Metabolic-Redox Circuits for Cancer Therapy. Trends Biochem Sci. 2019;44(5):401-14 (ESI高被引论文) .

14. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Nice EC, Wu M, Huang C, Wei Y. Identification of ANXA2 (annexin A2) as a Specific Bleomycin Target to Induce Pulmonary Fibrosis by Impeding TFEB-mediated Autophagic Flux. Autophagy. 2018;14(2):269-82.

15.Jiang J, Wang K, Chen Y, Chen H, Nice EC, Huang C. Redox regulation in tumor cell epithelial-mesenchymal transition: Molecular basis and therapeutic strategy. Signal Transduct Target Ther. 2017;2:e17036 (共同一作) .