2015年获得四川大学临床医学（八年制）博士学位，2018年至今在四川大学华西基础与法医学院从事博士后研究，入职人体解剖教研室，2018-2022年北达科他大学访问学者。主要研究传染病和炎症领域，尤其关注肠道和肺部疾病，通过系统生物信息学、网络药理学研究分析和体内外实验验证，进行免疫药理学的研究，筛选新的生物标志物、潜在治疗靶点和候选治疗药物。主持国家自然科学青年基金项目1项（布雷非德菌素A（BFA）调控cGAS/NLRP3/CASP1信号轴改善炎症性肠病的作用及机制研究）。以第一/共同第一作者在Theranostics,Semin Cancer Biol,Adv Exp Med Biol,J Vis Exp,Precis Clin Med等在内的国际学术期刊发表6篇学术论文。参加了人民卫生出版社《人卫3D系统解剖学》的编写工作。

（*共同第一作者，#共同通讯作者）

1. Zhihan Wang*, Kai Guo*, Pan Gao, Qinqin Pu, Ping Lin, Shugang Qin, Na Xie, Junguk Hur, Changlong Li#, Canhua Huang#, Min Wu#. Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease. Theranostics. 2021; 11(15):7491-7506.

2. Zhihan Wang*, Kai Guo*, Yingying Liu, Canhua Huang#, Min Wu#. Dynamic impact of virome on colitis and colorectal cancer: Immunity, inflammation, prevention and treatment. Semin Cancer Biol. 2022; 86(Pt 2):943-954.

3. Zhihan Wang*, Kai Guo*, Pan Gao, Qinqin Pu, Changlong Li#, Junguk Hur#, Min Wu#. Repurposable drugs for SARS-CoV-2 and influenza sepsis with scRNA-seq data targeting post-transcription modifications. Precis Clin Med. 2021; 4(4):215-230.

4. Zhihan Wang, Qinqin Pu, Canhua Huang#, Min Wu#. Crosstalk Between Lung and Extrapulmonary Organs in Infection and Inflammation. Adv Exp Med Biol. 2021; 1303:333-350.

5. Zhihan Wang*, Qinqin Pu*, Ping Lin*, Changlong Li#, Jianxin Jiang#, Min Wu#. Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression. J Vis Exp. 2019; 148:10.3791/59386.

6. Ning Wang*, Zhihan Wang*, Shihong Nie*, Linjiang Song, Tao He, Suleixin Yang, Xi Yang, Cheng Yi, Qinjie Wu#, Changyang Gong. Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo. Int J Nanomedicine. 2017; 12:1499-1514.

7. Kai Guo*,#, Dan Yombo*, Taylor Schmit*, Zhihan Wang, Zahrasadat Navaeiseddighi, Venkatachelem Sathish, Ramkumar Mathur, Min Wu, Bony Kumar, Junguk Hur#, and Nadeem Khan#. Cellular heterogeneity and molecular reprogramming of host response during influenza acute lung injury. J Virol. 2022; 96(21):e0124622.

8. Taylor Schmit, Kai Guo, Jitendra Kumar Tripathi, Zhihan Wang, Brett McGregor, Mitch Klomp, Ganesh Ambigapathy, Ramkumar Mathur, Junguk Hur, Michael Pichichero, Jay Kolls, M Nadeem Khan. Interferon-γ promotes monocyte-mediated lung injury during influenza infection. Cell Rep. 2022; 38(9):110456.

9. Ping Lin*,#, Guanwang Shen*, Kai Guo*,#, Shugang Qin*, Qinqin Pu, Zhihan Wang, Pan Gao, Zhenwei Xia, Nadeem Khan, Jianxin Jiang#, Qingyou Xia#, Min Wu#. Type III CRISPR-based RNA editing for programmable control of SARS-CoV-2 and human coronaviruses. Nucleic Acids Res. 2022; 50(8):e47.

10. Qinqin Pu*, Kai Guo*, Ping Lin*, Zhihan Wang, Shugang Qin, Pan Gao, Colin Combs, Nadeem Khan#, Zhenwei Xia#, Min Wu#. Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection. Signal Transduct Target Ther. 2021;6(1):210.

11. Ping Lin, Shugang Qin, Qinqin Pu, Zhihan Wang, Qun Wu, Pan Gao, Jacob Schettler, Kai Guo, Rongpeng Li, Guoping Li, Canhua Huang, Yuquan Wei, George Fu Gao, Jianxin Jiang#, Min Wu#. CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells. Mol Cell. 2020 Jun 4;78(5):850-861.e5.